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Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy 被引量：6

Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy
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摘要 Recent studies showed that pathology of alcoholic encephalopathy was associated with cerebral vascular damage.TMP（tetramethylpyrazine）is widely used in the treatment of cerebrovascular diseases,however,it has not been reported whether TMP can relieve alcohol-induced Recent studies showed that pathology of alcoholic encephalopathy was associated with cerebral vascular damage.TMP（tetramethylpyrazine）is widely used in the treatment of cerebrovascular diseases,however,it has not been reported whether TMP can relieve alcohol-induced
作者 LI Hui YANG Xue SHI Wei MA Zhao FENG Guang Kun YIN Yan Ling FAN Yan Xia JIANG Jie
机构地区 Department of Neurology Department of Neurology Department of gynecology and obstetrics Department of Emergency
出处 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2015年第9期691-695,共5页 生物医学与环境科学（英文版）
基金 supports from Shandong Academy of Medical Sciences,Electron Microscopy Laboratory of Shandong University Medical School Department of Neurology of Qilu Hospital of Shandong University
关键词 alcohol encephalopathy Alcohol saline relieve intake neuronal administration Figure tetramethyl alcohol encephalopathy Alcohol saline relieve intake neuronal administration Figure tetramethyl
分类号 R595.6 [医药卫生—内科学] R747.9 [医药卫生—神经病学与精神病学]
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参考文献10

  • 1Li H, Yang X, Shi W, et al. Protective effects of nimodipine on cerebrovascular function in chronic alcoholic encephalopathy. Int J Mol Med, 2014; 33, 201-8.
  • 2Tan W, Bailey AP, Shparago M, et al. Chronic alcohol consumption stimulates VEGF expression, tumor angiogenesis and progression of melanoma in mice. Cancer Biol Ther, 2007; 6, 1211-7.
  • 3Yeligar S, Tsukamoto H, Kalra VK. Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199. J Immunol, 2009; 183, 5232-43.
  • 4Kao TK, Ou YC, Kuo JS, et al. Neuroprotection by tetramethylpyrazine against ischemic brain injury in rats. Neurochem Int, 2006; 48, 166-76.
  • 5Tsai CC, Lai TY, Huang WC, et al. Tetramethylpyrazine as potassium channel opener to lower calcium influx into cultured aortic smooth muscle cells. Planta Med, 2003; 69, 557-8.
  • 6Cariboni A, Davidson K, Dozio E, et al. VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels. Development, 2011; 138, 3723-33.
  • 7Bekhite MM, Finkensieper A, Rebhan J, et al. Hypoxia, Leptin, and Vascular Endothelial Growth Factor Stimulate Vascular Endothelial Cell Differentiation of Human Adipose Tissue-Derived Stem Cells. Stem Cells Dev, 2013.
  • 8Zhang L, Deng M, Zhou S. Tetramethylpyrazine inhibits hypoxia-induced pulmonary vascular leakage in rats via the ROS-HIF-VEGF pathway. Pharmacology, 2011; 87, 265-73.
  • 9Lee WS, Yang HY, Kao PF, et al. Tetramethylpyrazine downregulates angiotensin II-induced endothelin-1 gene expression in vascular endothelial cells. Clin Exp Pharmacol Physiol, 2005; 32, 845-50.
  • 10Cao W, Zeng Z, Zhu YJ, et al. Effects of tetramethylpyrazine, a Chinese medicine, on plasma endothelin-1 levels during acute pulmonary hypoxia in anesthetized dogs. J Cardiovasc Pharmacol, 1998; 31 Suppl 1, S456-9.

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引证文献6

二级引证文献69

Biomedical and Environmental Sciences
2015年 第9期

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