酪酸梭菌活菌散与非营养性吸吮联合治疗早产儿喂养不耐受观察

Observation of Clostridium Butyricum Powder Combined with Non Nutritive Sucking on Feeding Intolerance in Preterm Infants

目的:观察酪酸梭菌活菌散与非营养性吸吮联合治疗早产儿喂养不耐受的疗效及安全性。方法:早产儿喂养不耐受住院患儿88例随机分为观察组和对照组。对照组患儿喂养方案以2006年制定的《中国新生儿营养支持临床应用指南》为准;观察组患儿在对照组基础上加用酪酸梭菌活菌散0.5 g,bid,鼻饲或奶瓶给药。结果:观察组患儿开始喂奶时间、呕吐腹胀消失时间、达全量胃肠内营养时间、恢复至出生体质量时间和住院时间均明显短于对照组(P<0.05)。治疗7 d后,观察组临床总有效率为95.45%,明显高于对照组的79.55%(P<0.05);观察组总并发症发生率明显低于对照组(P<0.05)。两组患儿治疗期间未发生明显药品不良反应。结论:酪酸梭菌活菌散与非营养性吸吮联合治疗早产儿喂养不耐受的疗效优于单纯的非营养性吸吮治疗,安全性好,能缩短患儿开始喂奶时间、呕吐腹胀消失时间、恢复出生体质量时间及达全胃肠喂养时间,并能减少并发症。

Objective：To observe curative effect and safety of clostridium butyricum powder combined with non nutritive sucking on feeding intolerance in preterm infants. Methods：88 cases of preterm infants with feeding intolerance were divided into observation group and control group at random. The feeding method of children in control group were accorded with Guide for Clinical Application of Nutrition Support in Critical Neonates in China, while the children in observa- tion group were additionally given clostridium butyricum powder 0.5 g per time, twice a day, by nasal or bottle feeding. Re- suits：The start feeding time, vomiting and abdominal distention disappear time, full enteral nutrition time, recovery time to reach weight at birth and length of stay （LOS） of children in observation group were much shorter than those in control group（P 〈 0.05 ）. After 7 dayslnedical treatment, total clinical efficiency of children in observation group （95.45%） was much higher than that in control group （79.55% ,P 〈 O. 05）. The occurrence rate of total complication of children in ob- servation group was much lower than that in control group （ P ~ 0.05）. There was no obviously adverse drug reactions in two groups during treatment. Conclusion： Clostridium butyricum powder combined with non nutritive sucking had more fa- vorable curative effect on feeding intolerance in preterm infants than pure non nutritive sucking, and with better saftey, which can shorten start feeding time, vomiting and abdominal distention disappear time, recovery time to reach weight and full enteral nutrition time and can reduce the occurrence rate of complication.