我院耐左氧氟沙星大肠埃希菌的耐药性分析

Analysis on Drug Resistance of Escherichia Coli Resistant to Levofloxacin in Our Hospital

目的：分析我院耐左氧氟沙星大肠埃希菌的耐药性特点,为临床预防、控制、治疗大肠埃希菌感染提供依据。方法：对我院2014年2月1日~2015年2月1日临床分离的140株大肠埃希菌药敏试验结果进行统计分析。结果：140株大肠埃希菌中共检出耐左氧氟沙星75株,检出率为53.57%,主要从尿液（46.47%）中检出,其次为痰（14.67%）。除哌拉西林/他唑巴坦、头孢西林、头孢替坦、厄他培南、亚胺培南/西司他丁、庆大霉素、妥布霉素、呋喃妥因、复方磺腹甲噁外,耐左氧氟沙星菌株对氨苄西林、氨苄西林/舒巴坦、头孢他啶、头孢曲松、头孢匹美、氨曲南、阿米卡星、环丙沙星和产超广谱β-内酰胺酶（ESBLs）的耐药率明显高于非耐左氧氟沙星的菌株（P〈0.05或P〈0.01）。结论：大肠埃希菌对部分常用抗菌药的耐药性较高,应加强临床的耐药性监测,合理使用抗菌药物,延缓细菌耐药性的产生。

Objective：To analyze the drug resistance characteristics of Escherichia coli resistant to levofloxacin, for clinical prevention, control and treatment of Escherichia coli infection to provide reference. Methods： the resistance feature in 140 strains of Escherichia coli collected in our hospital from February 1st, 2014 to February lst,2015 were statisti- cally analyzed. Results：Total of 75 strains resisted to levotloxacin were detected in 140 strains of Escherichia coli, and the detection rate was 53.57%. The main common specimens in which strains resisted to levotloxacin were detected were in turn the urina （46.47%） and the sputum （ 14.67% ）. Except for piperacillin/tazobala, cefacillin, cefotetanertapenem, imipenem/cilastatin, gentamycin, tobramycin, furantotin, SMZ plus TMP, the resistance rate of levotloxacin-resistant strains were significantly higher than that of non-Levofloxacin-resistant strains to ampicillin, ampiciUin/sulbactam, ceftazi- dime, ceftriaxone, cefepime, azactam, amikacin, ciprofloxacin, ESBLs （ P 〈 0.05 or P 〈 0.01 ）. Conclusion： Escherichia coli of some commonly used antibiotic resistance was higher, should strengthen the drug resistance of clinical monitoring, rational use of antimicrobial agents, delay the produce of antibiotic resistance.