摘要
目的 :观察大鼠 7周大负荷游泳训练及人参二醇组皂甙 (PDS)对大鼠股四头肌α -肌动蛋白mRNA表达的影响。方法 :采用Northernblot分析 7周大负荷游泳训练后恢复期大鼠股四头肌α -肌动蛋白mRNA表达水平及PDS对其影响。结果 :α-肌动蛋白mRNA杂交信号的扫描积分光密度值 (A) ,运动·盐水组较安静组略强 ;运动·PDS,扫描积分光密度值 (A)显著强于运动·盐水组和安静组 ,运动·甲睾组与运动·盐水组表达无明显差异。结论 :PDS可提高长期耐力运动大鼠股四头肌α -肌动蛋白mRNA表达 ,从而提高耐力运动能力 ;长期应用外源性雄激素对耐力训练大鼠股四头肌α -肌动蛋白无明显提高 ,这可能与外源睾酮对内源性睾酮分泌的抑制有关。
AIM: To study the effects of 7 weeks prolonged haevy load swimming and Panaxadiol Saponins (PDS) on the expression of α-actin in quadriceps muscle of thigh in rats. METHODS: After 7 weeks prolonged heavy load swimming training, the expression of α-actin in quadriceps muscle of thigh was quantitatively examined by Northern blotting analysis in the condition with or without PDS treatment. RESULTS: The expression of α-actin in rat quadriceps muscle of thigh in exercise+PDS group was significantly higher than that in sedentray control group and exercise+saline group at 24 th hour after intensive training. No statistical difference between exercise+androsan group and exercise+saline group was observed.CONCLUSION: PDS enhanced α-actin expression in quadriceps muscle of thigh in rats.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2002年第8期942-945,共4页
Chinese Journal of Pathophysiology
基金
卫生部科研基金资助项目 (No.98-2- 182)
