复方七叶皂苷钠凝胶治疗老年四肢骨折肿胀疼痛临床研究

Clinical Research on Swelling and Pain due to Senile Limb Fracture Treated with Compound Sodium Aescinate Gel

目的:观察复方七叶皂苷钠凝胶治疗老年四肢骨折肿胀疼痛的临床疗效。方法:将60例患者随机分为治疗组和对照组,每组各30例。对照组采取局部麻醉下骨折手法复位,同时予以功能锻炼;治疗组在对照组基础上加用复方七叶皂苷钠凝胶。比较两组患者治疗前后中医证候评分、治疗4周、12周后的骨痂骨密度和治疗前、治疗3 d、14 d后的肿胀面积。结果:两组患者治疗4周后的压痛、疼痛、肿胀、功能障碍和瘀斑评分显著低于治疗前,治疗组治疗4周后的压痛、疼痛、肿胀、功能障碍和瘀斑评分显著低于对照组,差异均具有统计学意义(P<0.05)。两组患者治疗4周、12周后的骨痂骨密度逐渐升高,且治疗组治疗4周、12周后的骨痂骨密度均显著高于同期对照组,差异均具有统计学意义(P<0.05)。治疗组治疗3 d、14 d的肿胀面积显著小于同期对照组(P<0.05)。两组有效率比较,差异具有统计学意义(P<0.05)。结论:复方七叶皂苷钠凝胶对老年四肢骨折后的肿胀、疼痛症状具有较好的缓解作用。

Objective： To observe the clinical effects of Compound Sodium Aescinate Gel on swelling and pain due to senile limb fracture. Methods： 60 cases were randomized into treatment group and control group,with 30 cases in each group. Control group were given manual reduction under local anesthesia and given functional training simultaneously while treatment group were added with Compound Sodium Aescinate Gel. In the two groups,the TCM symptom scores,the bone mineral density of callus after 4weeks and 12 weeks as well as the swelling area before the treatment on the 3rd day and 14 th days of the treatment were compared. Results： After 4 weeks of the treatment for both groups,the tenderness,pain,swelling,functional disorder and ecchymosis score were marked lower than these before treatment,and the scores in treatment group were lower than control group; the difference had statistical significance（ P 〈0. 05）. After 4 weeks and 12 weeks of treatment,the bone mineral density of callus in both groups gradually increased,and that in treatment group were significantly higher than that in control group; the difference had statistical significance（ P 〈0. 05）. On the 3rd day and 14 th day of the treatment,the swelling area in treatment group were obviously smaller than that in control group（ P 〈0. 05）. The difference of the effective rates between the two groups had statistical significance（ P 〈0. 05）. Conclusion： Compound Sodium Aescinate Gel has good relieving effects on the swelling and pain due to senile limb fracture.