中西医结合治疗急性发作期肺心病痰浊壅肺证临床研究

Clinical Research of Integrated Chinese and Western Medicine for Treating Pulmonary Heart Disease at Acute Attack Stage Due to Phlegm-Turbidity Obstructing the Lung Syndrome

目的:观察中西医结合治疗急性发作期肺心病痰浊壅肺证的疗效以及对血清肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)含量的影响。方法:选择急性发作期肺心病痰浊壅肺证患者92例,按照随机数字表法分为观察组和对照组,每组各46例。所有患者均给予常规对症治疗,观察组另加用固本咳喘片治疗。结果:观察组治疗后中医临床症状评分均明显低于对照组(P<0.01);观察组有效率为91.30%,对照组有效率为71.73%,观察组明显优于对照组(P<0.05);观察组治疗后Pa CO2比对照组降低更为明显,Pa O2和心输出量较对照组明显升高(P<0.05);观察组治疗后血清TNF-α和IL-6均低于对照组(P<0.01)。结论:中西医结合治疗急性发作期肺心病痰浊壅肺证疗效显著。

Objective： To observe the efficacy of integrated Chinese and western medicine for treating pulmonary heart disease at acute attack stage due to phlegm-turbidity obstructing the lung syndrome,and the influence of it on the content of TNF-αand IL-6.Methods： 92 cases with pulmonary heart disease at acute attack stage due to phlegm-turbidity obstructing the lung syndrome were divided into observation group and control group according to the number table,with 46 cases in each group. All patients were given routine symptomatic treatment. Observation group were added with Guben Kechuan Tablets. Results： After the treatment,the TCM clinical symptom scores in observation group were significantly lower than those in control group（ P 〈0. 01）. The effective rate was 91. 30% in observation group and 71. 73% in control group; observation group were marked higher than control group（ P 〈0. 05）. The decline of Pa CO2 in observation group were much more obvious than that in control group（ P 〈0. 05）. The Pa CO2 and heart output quantity got apparently increased compared with control group（ P 〈0. 05）. The levels of serum TNF-αand IL-6 in observation group were both lower than these in control group（ P 〈0. 01）. Conclusion： Integrated Chinese and western medicine has remarkable therapeutic effects on pulmonary heart disease at acute attack stage due to phlegm-turbidity obstructing the lung syndrome,which can significantly improve the clinical symptoms and the levels of Pa CO2 and heart output quantity,lower the content of serum TNF-αand IL-6.