系统性红斑狼疮相关骨质疏松

Emphasis on systemic lupus erythematosus and osteoporosis

随着对系统性红斑狼疮诊治认识的发展,骨质疏松作为其长期并发症之一得到更多的关注与研究。系统性红斑狼疮合并骨质疏松的原因包括疾病本身的病程及损害,慢性多器官功能异常,治疗药物因素等多方面,其中除传统研究中证明的因素外,系统活动性炎症,体内激素水平、月经周期,神经精神因素等也参与其发生,最终表现为骨量流失增加,骨组织的细微结构破坏导致承重力下降,甚至骨折,治疗中应予以重视。

As the survival of patients with systemic lupus erythematosus （SLE） has extended obviously osteoporosis as one of its long- term complications gets more attention. The causes of steoporosis in SLE patients include disease duration, systemic inflammation, chronic multiple-organ damage, medications, in addition to the traditional factors, for inatance, hormone levels, menstrual cycle, and neuropsychological factors. Osteoporosis characterized by increased bone loss, subtle structural failure will eventually lead to the decrease of the bearing force of bone tissue and fracture.