系统性红斑狼疮并发神经精神性狼疮

Diagnosis and treatment of neuropsychiatric lupus

神经精神性狼疮(NPSLE)严重影响系统性红斑狼疮(SLE)患者的预后,早期诊断和恰当治疗十分重要。NPSLE主要累及中枢神经系统(CNS),较少累及外周神经系统(PNS)。美国风湿病协会推荐了12种可以认定为NPSLE的CNS症状和7种PNS症状。由于NP-SLE的诊断尚缺乏金标准,鉴别诊断非常重要。NP-SLE的治疗仍然以糖皮质激素和其他免疫抑制剂为主。

Neuropsychiatric syndromes of systemic lupus erythematosus （NP-SLE） severely affect the prognosis of systemic lupus erythematosus （SLE）. Early diagnosis and proper treatment are critical. NP-SLE generally divided into central neural system （CNS） involvements and peripheral neural system （PNS） involvements.The American College of Rheumatology proposed case definitions for 12 CNS syndromes and 7 PNS syndromes of NPSLE. Because no gold standard＇ approach is available at present, the differential diagnose for NPSLE is necessary. To date, corticosteroids and Other immunosuppressive agents remain the primary treatment of NPSLE.