期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

促甲状腺素受体抗体两种亚型研究进展 被引量：4

Updates in studies on two kinds of subtypes of thyrotropin receptor antibody
原文传递
导出
摘要 1促甲状腺素受体（TSHR）及其抗体（TRAb） TSHR为G蛋白偶联受体超家族的成员之一，具有7个跨膜结构域，长度为764个氨基酸。TSHR胞外域通过铰链跨膜与胞内域连接，其亚结构是异质二聚体，其中A亚单位通过二硫键结合至跨膜B亚单位。甲状腺细胞表面，铰链区的二硫键断裂导致A亚基脱落，成为Graves病（GD）的自身抗原，
作者 刘姗姗 李玉姝
机构地区 中国医科大学内分泌研究所 中国医科大学附属第一医院内分泌科
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2015年第10期873-875,共3页 Chinese Journal of Practical Internal Medicine
基金 国家自然科学基金(81170731)
关键词 促甲状腺素受体 促甲状腺素受体刺激性抗体 促甲状腺素受体阻断性抗体 TSH receptor TSH receptor stimulation antibody TSH receptor stimulation-blocking antibody
分类号 R581.1 [医药卫生—内分泌]
  • 相关文献

参考文献23

  • 1Wiersinga WM. Thyroid autoimmunity[J]. Endocr Dev, 2014, 26: 139-157.
  • 2Diana T, Brown KS, Bossowski A, et al. Clinical relevance of thyroid- stimulating autoantihodies in pediatric graves disease-a multicenter study[J]. Clin Endocrinol Metab, 2014, 99(5): 1648-1655.
  • 3Schwarz-Lauer L, Chazenbalk GD, Mclachlan SM, et al. Evidence for a simplified view of autoantibody interactions with the thyrotropin receptor[J]. Thyroid, 2002, 12(2): 115-120.
  • 4Evans M, Sanders J, Tagami T, et al. Monodonal autoantibodies to the TSH receptor, one with stimulating activity and one with blocking activity, obtained from the same blood sample[J]. Clin Endocrinol (Oxf), 2010, 73(3): 404-412.
  • 5Giuliani C, Cerrone D,Harii N, et al. A TSHr-LH/CGr Chimera that measures functional TSAb in Graves' Disease[J]. J Clin Endocrinol Metab, 2012, 97(7): E1106-115.
  • 6Giuliani C1, Cerrone B, Harii N, et al. A TSHR-LH/CGR Chimera that measures functional Thyroid-Stimulating Autoantibodies (TSAb) can predict remission or recurrence in Graves' patients undergoing antithyroid drug (ATD) treatment[J]. J Clin Endocrinol Metab. 2012, 97(7): E1080-1087.
  • 7Hwang S, Shin DY, Song MK, et al. High cut-offvalue of a chimeric TSH receptor (Mc4)-based bioassay may improve prediction of relapse in Graves' disease for 12 months [J]. Endocrine, 2015, 48 (1): 89-95.
  • 8Li Yj Kim J, Diana Tj et al. A novel bioassay for anti-thyrotrophin receptor autoantibodies detects both thyroid-blocking and stimulating activity[J]. Clin Exp Immunol, 2013, 173(3): 390-397.
  • 9Zakarija M, McKenzie JM, Munro DS. Immunoglobulin G inhibitor of thyroid-stimulating antibody is a cause of delay in the onset of neonatal Graves' disease[J]., clin Invest, 1983, 72(4): 1352-1356.
  • 10Tamai H, Kasagi K, Takaichi Y, et al. Development of spontaneous hypothyroidism in patients with Graves disease treated with antithyroidal drugs: clinical, immunological, and histological findings in 26 patients [J]. J Clin Endocrinol Metab, 1989, 69 (1): 49-53.

二级参考文献11

  • 1陈卫中,倪宗瓒,潘晓平,刘元元,夏彦.用ROC曲线确定最佳临界点和可疑值范围[J].现代预防医学,2005,32(7):729-731. 被引量：208
  • 2Gonzalez C, Hernando M, Cava F, et al. Biological variability of thyroid autoantibodies (antkTPO and anti-Tg) in clinically and bio chemically stable patients with autoimmune thyroid discase[J]. J Clin Lab Anal, 2002, 16(1): 37 39.
  • 3Tarnaki H, Katsurnaru H, Amino N, et al. Usefulness of thyroglobulin antibody detected by ultrasensitive enzyme irnmunoassay: a good parameter for immune surveillance in healthy subjects and for prediction of post partum thyroid dysfunction[J]. Clin Endocrinol Oxf, 1992, 37(3): 266- 273.
  • 4Kamijo K. Study on cutoff value setting for differential diagnosis be tween Graves' disease and painless thyroiditis using the TRAb (ElecsysTRAb) nescenee ment v/a the fully automated electroehemilumiy system[J]. Endocr J, 2010, 57(10); 895-902.
  • 5Iitaka M, Morgenthaler NG, Momotami N, et al. Stimulation of thyroid-stimulating hormone (TSH) receptor antibody production following painless thyroiditis[J]. Clin Endocrinol (Oxf), 2004, 60 (1): 49 53.
  • 6Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T4, and thyroid antibodies in the United States population(1988 to 1994 ) National Health and Nutrition Examination Survey (NHANES III)[J].J Clin Endocrinol Metab, 2002, 87(2): 489-499.
  • 7Takasu N, Yoshimura Noh J. Hashimoto's thyrodidist: TGAb, TPOAb, TRAb and recovery from hypothyroidism[J]. Expert Rev Clin lmmunol, 2008, 4(2): 221-237.
  • 8宋武战,池君,汪静.促甲状腺激素受体抗体(TRAb)测定的临床价值[J].放射免疫学杂志,2007,20(5):399-401. 被引量：33
  • 9杨士军,谭维琴,刘满庆.TGA、TPOAb、TRAb测定对甲状腺疾病的诊断价值[J].放射免疫学杂志,2008,21(4):321-322. 被引量：20
  • 10刘超,杨昱,陈立立.甲状腺自身抗体的基础和临床进展[J].内科理论与实践,2010,5(2):139-146. 被引量：32

共引文献30

同被引文献25

引证文献4

二级引证文献23

中国实用内科杂志
2015年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部