循环肿瘤细胞在乳腺癌中的临床意义及检测方法

The clinical significance and detecting methods of circulating tumor cells in breast cancer

乳腺癌预后的主要影响因素是术后复发和转移,而乳腺癌在肿瘤发展的早期就已经发生了转移,在乳腺癌外周血中发现肿瘤细胞,对早期诊断及治疗有指导意义。循环肿瘤细胞已经被证明是转移性乳腺癌预后的标志物。然而,最新研究表明循环肿瘤细胞在早期乳腺癌中亦可提示预后不良。目前,循环肿瘤细胞检测方法主要由富集分离法和分析鉴定法两部分组成,应选择合适的方法检测循环肿瘤细胞,以提高检测效率。探索循环肿瘤细胞与乳腺癌的关系,有助于乳腺癌早期检测及合理治疗。

Metastasis had been occurred in the early breast cancer,and the main influencing factors of prognosis were recurrence and metastasis after operation. So,monitoring tumor cells in peripheral blood was significance to diagnosis and treatment. Circulating tumor cells（CTC）have been shown to be a poor prognostic marker in metastatic breast cancer. However,several recent studies suggest that the presence of CTC in early breast cancer may also suggest a poorer prognosis. At present,the detection methods of circulating tumor cell were composed of enrichment separation and analysis identify methods. Choosing appropriate methods to detect circulating tumor cells could improve the efficiency of detection. Exploring the relation between circulating tumor cell and breast cancer may avail the early diagnosis and effective treatment of breast cancer.