清宣止咳颗粒治疗小儿上呼吸道感染的效果

Effect on Qingxuan Zhike Particles in the treatment of children with up-per respiratory infection

目的观察清宣止咳颗粒治疗小儿上呼吸道感染的效果。方法选择2014年2～7月在天津市人民医院住院治疗的上呼吸道感染患儿122例，完成研究者106例，采用随机数字表法将其分为治疗组和对照组。各53例。对照组给予利巴韦林抗病毒以及对症治疗，利巴韦林10mg／（kg·d），每日3次。治疗组在西医抗病毒、对症治疗基础上加服清宣止咳颗粒，1～3岁每次1／2包，4～6岁每次3／4包，7～14岁每次1包，每日3次，温水冲服。两组患者疗程均为7d。观察两组患者的临床疗效、临床症状及不良反应发生情况。结果治疗组总有效率为98．1％（52／53），痊愈率为92．5％（49／53）；对照组总有效率为96．2％（51／53），痊愈率为73．6％（39／53）。两组总有效率比较差异无统计学意义（P〉0．05），但治疗组痊愈率显著高于对照组，差异有统计学意义（P〈0．05）。治疗组治疗后咳嗽咳痰、发热症状的发生率低于对照组[15．1％（8／53）比35．8％（19／53），3．8％（2／53）比17．0％（9／53）]，差异有统计学意义（P〈0．05）；治疗组鼻塞流涕、咽痛咽痒症状的发生率与对照组比较，差异无统计学意义（P〉0．05）。治疗组并发症发生率为1．9％（1／53），对照组为7．5％（4／53），两组并发症发生率比较差异无统计学意义（χ2=1．889，P〉0．05）。结论对于急性上呼吸道感染患儿而言，在西医常规抗病毒加对症治疗的基础上，加服清宣止咳颗粒。能够显著提高临床疗效，缓解临床症状，且安全性好，服用方便，值得临床推广使用。

Objective To observe the effect of Qingxuan Zhike Particles in the treatment of children with upper respiratory infection. Methods One hundred and twenty two cases of children with upper respiratory infection hospitalized in Tianjin People＇s Hospital from February to July 2014 were selected, 106 cases finished the study and they were divided into treatment group and control group, with 53 cases in each group. The control group was given Ribavirin for anti- virus and symptomatic treatment, Ribavirin 10 mg/（kg·d）, three times a day. On basis of western medicine of anti-virus and symptomatic treatment, the treatment group was added with Qingxuan Zhike Particles, once 1/2 package 1-3 years old, once 3/4 package 4-6 years old, once 1 package 7-14 years old, 3 times a day, administered after dissolved with warm water. The course of both groups was 7 d. The clinical effect, the occurrence of clinical symptoms and adverse reactions of the two groups were observed. Results The total effective rate of treatment group was 98.1% （52/53）, the cure rate was 92.5% （49/53）; the total effective rate of control group was 96.2%（51/53）, the cure rate was 73.6% （39/ 53）. There was no statistically significant difference of the total effective rate between the two groups （P 〉 0.05）, while the cure rate of treatment group was higher than that of control group, the difference was statistically significant （P 〈 0.05）. After treatment, the incidence of cough and expectoration, fever in the treatment group was lower than that of control group [15.1% （8/53） vs 35.8% （19/53）, 3.8% （2/53） vs 17.0% （9/53）], the differences were statistically significant （P 〈 0.05）; the incidence of nasal obstruction and running nose, throat sore and itching of the treatment group had no statistically significant differences compared with control group （P 〉 0.05）. The incidence of complications in the treatment group was 1.9% （1/53）, which of control group was 7.5% （4/53）, there was no statistically significant difference of the incidence of complications between the two groups （χ2=1.889, P 〉 0.05）. Conclusion For children with acute upper respiratory infection, on basis of western medicine of anti-virus and symptomatic treatment, the added Qingxuan Zhike Particles can significantly improve clinical effect, relieve clinical symptoms, and the safety is good, which is easy to take and worthy of clinical promotion and application.