质子感知受体在呼吸系统疾病中的作用

Proton sense receptors in the role of respiratory disease research

G蛋白耦联受体家族卵巢癌G蛋白耦联受体1亚家族的OGR1、T细胞死亡耦联基因8、G蛋白耦联受体4及诱导细胞停滞于G2／M期的G蛋白耦联受体G2A，这4种受体是新近发现的一类质子感知受体。该类受体广泛分布于人的各种正常组织和肿瘤组织细胞中，不仅与肿瘤的发生和转移等病理过程有关，还与炎症反应、免疫系统和血管系统等病理生理过程有关。这篇文章综述了在呼吸系统疾病中，质子感知受体的作用及其相关的信号通路。

G protein coupled receptor family of ovarian cancer G protein coupled receptor 1 （OGR1） ,T cell death coupled gene 8 （TDAG8）,G protein coupled receptor 4 （GPR4） and stagnation of induced cells in G2/M phase of G protein coupled receptor G2A, these four receptors are a newly discovered type of proton sensory receptors. They are widely expressed in both normal and tumor cells in human body, not only related tO the occurrence and metastasis of tumor and other pathological process, hut also related to inflammatory response, the immune system, vascular system and other pathological physiological processes. This article reviewed the regulatory role of these proton-sensing receptors and its function in the respiratory system disease.