血浆D-二聚体检验对急性白血病患者病情进展及疗效评估的临床意义

Clinical significance of plasma D-dimer detection in the prognosis and efficacy evaluation of acute leukemia

目的探讨血浆D-二聚体检验对急性白血病患者病情进展及疗效评估的临床意义。方法选择180例急性白血病患者作为观察组研究对象,另外选择同期60例健康体检者作为对照组研究对象,应用免疫比浊法检测血浆D-二聚体水平。对初治期(180例)、缓解期(123例)、复发期(38例)患者进行动态监测D-二聚体,并对比分析急性非淋巴细胞白血病(ANLL)与其他类型白血病患者的血浆D-二聚体水平。结果与对照组相比,初治期、复发期急性白血病患者的D-二聚体水平均明显升高(均P<0.05);与缓解期相比,初治期、复发期急性白血病患者D-二聚体水平均明显升高(均P<0.05);对照组缓解期急性白血病患者D-二聚体水平差异无统计学意义(P>0.05);初治期与复发期急性白血病患者D-二聚体水平差异无统计学意义(P>0.05)。与其他类型急性白血病相比,ANLL患者初治期D-二聚体水平明显升高(P<0.05),但缓解期两组D-二聚体水平比较,差异没有统计学意义(P>0.05)。结论血浆D-二聚体可反映急性白血病患者病情变化,动态监测D-二聚体水平有利于病情观察及疗效评估。

Objective To explore the clinical significance of plasma D-dimer detection in the prognosis and efficacy evaluation of acute leukemia. Methods The 180 patients with acute leukemia were selected as the subjects of observation group and the 60 healthy examinations were enrolled in the same period as the control subjects. The plasma D-dimer levels were detected by the immune turbidimetric method. The plasma D-dimer levels were dynamically monitored for the patients in the initial treatment period（ 180 cases）,remission period（ 123 cases） and recurrence period（ 38 cases）. The comparison analysis of plasma D-dimer levels was done for patients with acute non-lymphocytic leukemia（ ANLL） and other types of leukemia. Results Compared with the control group,the D-dimer levels during the period of initial treatment and recurrence for acute leukemia patients were significantly increased（ P〈0. 05）; Compared with the remission period,the plasma D-dimer levels in the periods of initial treatment and recurrence were obviously increased（ P〈0. 05）,however,compared with the control group,the D-dimer level in the remission period was slightly increased with non-statistical difference（ P〈0. 05）; Compared with the initial treatment period,the D-dimer level in the recurrence period was slightly decreased with non-statistical difference（ P〉0. 05）; Compared with the other types of leukemia,the D-dimer levels in the initial treatment period for ANLL patients were significantly increased（ P〈0. 05）,however,the comparison of D-dimer levels in the ANLL and other type leukemia during the remission period were non-statistical difference（ P〈0. 05）. Conclusion The plasma D-dimer level can response the disease changes of acute leukemia,and dynamic monitoring of D-dimer levels can conductive to disease observation and efficacy evaluation.