大黄素与白藜芦醇治疗重症急性胰腺炎的作用机制对比及其展望

Mechanisms of action of emodin and resveratrol in severe acute pancreatitis: A comparison

急性胰腺炎(acute pancreatitis,AP)是临床上常见的急腹症之一,约20%发展为重症急性胰腺炎(severe acute pancreatitis,SAP).微循环障碍、白细胞过度活化、活性氧的大量释放、炎症因子过表达、细胞凋亡紊乱和钙超载在SAP的发展过程中起重要作用.大量文献报道中药对SAP有较好的疗效.近十年来发现大黄素与白藜芦醇在治疗SAP动物模型研究十分活跃.本综述旨在归纳大黄素、白藜芦醇治疗SAP实验研究的作用机制,通过从传统中药学及现代药理学角度对比分析二者在治疗SAP作用及机制的异同点,为临床开发新的治疗SAP的中药复方注射液提供新的思路.

Acute pancreatitis（AP） is a common acute abdominal disease,and 20%of AP cases progress to severe acute pancreatitis（SAP）.Current studies have found that pancreatic microcirculation disturbance,leukocyte over-activation,inflammatory mediator overexpression,cell apoptosis disorders in damaged tissue,and calcium overload play important roles in SAP progression.Numerous studies have shown that traditional Chinese medicine（TCM） has a protective effect on SAP.In recent ten years,emodin and resveratrol are hot spot in the field of research on the treatment of SAP animal models with TCM.This review attempts to illuminate and compare the potential mechanisms of action of emodin and resveratrol in SAP from the perspective of traditional Chinese pharmacology and modern pharmacology.