干扰上皮细胞能量代谢对炎症性肠病发病的影响

Abnormal epithelial cell energy metabolism influences pathogenesis of inflammatory bowel disease

炎症性肠病(inflammatory bowel disease,IBD)的病因和发病机制尚不明确,结肠黏膜屏障损伤是关键因素.近几十年研究认为,干扰上皮组织的能量代谢会引发肠上皮细胞间隙增宽,细菌跨膜易位增多,黏液分泌减少等肠黏膜屏障功能紊乱.细菌、抗原等物质穿过肠黏膜屏障,进入固有层激活炎症反应,启动炎症性肠病.能量燃料丁酸盐缺乏,线粒体病理改变是肠上皮能量异常的原因.改善能量代谢,保护线粒体功能等方法,能缓解IBD的严重性,减少复发,为IBD的治疗提供了新的策略.

Etiology and pathogenesis of inflammatory bowel disease（IBD） are not clear,but colonic mucosal damage is known to be a critical factor.In recent decades,many studies suggest that interfering with the energy metabolism of epithelial tissue could result in the widening of intestinal epithelial cell gap,increased bacterial translocation across the epithelium,decreased mucus secretion,and intestinal mucosal barrier dysfunction.Bacteria and antigens adhere to the intestinal mucosa,enter into the lamina propria,activate inflammation,and initiate the pathogenesis of IBD.The lack of energy fuel butyrate and mitochondrial dysfunction are the causes of abnormal energy metabolism of the intestinal epithelium.Improving energy metabolism and protection of mitochondrial function can alleviate the seriousness of IBD,reduce recurrence,and provides a new strategy for the treatment of IBD.