Cav3．2通道在伤害性感受中的作用

The nociception role of Cav3.2 calcium channel

背景疼痛是危害人类健康，影响人类生存质量的重要因素，但目前可用于临床治疗的手段尚不能满足患者的无痛要求，且存在不同程度的副作用，其主要原因之一是目前对疼痛的产生机制尚未完全明了。最近的研究表明，T型钙通道Cav3．2亚型在疼痛信号转导中起重要作用。目的综述T型钙通道Cav3．2亚型在痛觉传导中的作用。内容阐述位于背根神经节（dorsalrootganglion，DRG）的T型钙通道参与传递生理性疼痛（疼痛感知）和病理性疼痛（神经病理性疼痛）伤害性刺激信号。趋向T型钙离子通道可调控疼痛伤害性刺激信号转导，并可作为可能的疼痛治疗靶点。

Background Some of the earliest detailed descriptions of biophysical properties of low voltage-activated or transient （T） type Calcium channels were done using in vitro preparation of primary sensory or dorsal root ganglion （DRG） neurons that are known for their functional role in processing pain signals. However, in spite of these early discoveries, T-type calcium channels were not implicated in sensory transmission in general and pain processing （nociception） in particular until recently. Objective To summarize the important role of peripheral T-type Calcium channels in boosting nociceptive transmission. Content T-type calcium channels in peripheral sensory neurons play important role under physiological conditions （e.g. acute noeiceptive pain ） and to pain processing under pathological conditions. Trend peripheral T-type Calcium channels in nociception and the value of these channels as cellular targets for potential drug developments.