凉血活血方剂治疗寻常型进行期银屑病的疗效观察

Effects of Blood-cooling-and-activating Formula on Vulgaris Psoriasis in Progressive Stage

目的:观察凉血活血方剂与银屑康胶囊治疗寻常型进行期银屑病的临床疗效。方法:纳入寻常型进行期银屑病患者130例,随机分为治疗组与对照组,每组65例。治疗组予凉血活血方剂口服,对照组予银屑康胶囊口服。观察两组患者治疗前后银屑病皮损面积和严重程度指数评分(PASI)、3个疗程后临床疗效以及肝肾功能等指标。结果:治疗3个疗程后,治疗组PASI评分为(3.65±2.06)分,对照组PASI评分为(6.25±2.36)分,治疗组明显低于对照组(P<0.05);治疗组总有效率为95.4%,对照组总有效率为84.6%,治疗组明显高于对照组(P<0.05);肝肾功能等安全性指标方面,两组比较,差异均无统计学意义(P>0.05)。结论:凉血活血中药方剂治疗寻常型进行期银屑病临床疗效较好,能够有效改善患者的皮损状况,且不良反应较少。

Objective： To observe the clinical effects of blood-cooling-and-activating formula and psoriasis healthy capsule on vulgaris psoriasis in progressive stage. Method： The 130 patients with clinical vulgaris psoriasis in progressive stage were randomly divided into treatment group and control group, with 65 patients each. The treatment group was given blood-coolingand-activating formula, and the control group was treated with psoriasis healthy capsule. The psoriasis area and severity index（PASI） scores of the two groups, the clinical effects after 3 courses of treatment as well as their indexes of liver and kidney functions before and after treatment were observed. Results： After 3 courses of treatment, the PASI score of the treatment group was（3.65±2.06） and that of the control group was（6.25±2.36）. The PASI score of the treatment group was obviously lower than that of the control group（P0.05）. The total effective rate of the treatment group was 95.4%, and that of the control group was84.6%, the experimental group was significantly higher than that of the control group（P0.05）. In addition, the difference between the safety indicators such as liver and kidney functions of the two groups was of no statistical significance（P0.05）. Conclusion： Blood-cooling-and-activating formula has good clinical effect on vulgaris psoriasis in progressive stage, can effectively improve the patients＇ skin damage condition and has less adverse reactions.