宫血宁胶囊联合去氧孕烯炔雌醇片治疗功能性子宫出血的临床研究

Clinical study on Gongxuening Capsules combined with Desogestrel Ethinylestradiol Tablets in treatment of uterine hemorrhage

目的：探讨宫血宁胶囊联合去氧孕烯炔雌醇片治疗功能性子宫出血的疗效。方法选择聊城市第二人民医院2013年1月-2014年12月收治的子宫出血患者80例，随机分为治疗组和对照组，每组各40例，对照组患者在术后第一次来月经的5 d之内，口服去氧孕烯炔雌醇片150 mg，于20-30 d后再口服1次，此后依次间隔同样时间连续口服6次。治疗组在对照组的基础上，术后7 d开始服用宫血宁胶囊，4粒/次，3次/d，连续服用6个月。所有患者均随访3年。比较两组患者的临床疗效，黄体生成素（LH）、卵泡刺激素（FSH）及雌二醇（E2）水平，以及控制出血时间与完全止血时间，同时比较两组患者的不良反应发生情况。结果治疗组患者的有效率为97.5%，明显高于对照组（77.5%），两组比较差异有统计学意义（P＜0.05）。两组患者治疗后血清中LH、FSH、E2水平均较同组治疗前明显降低，比较差异具有统计学意义（P＜0.05）；对照组和治疗组治疗后的各激素水平比较差异无统计学意义。两组患者治疗后中医证候积分均较同组治疗前明显下降，且治疗组治疗后的下降程度明显高于对照组，差异具有统计学意义（P＜0.05）。治疗组患者控制出血时间与完全止血时间均较对照组短，比较差异均具有统计学意义（P＜0.05）。治疗组患者的不良反应发生率为7.5%，与对照组比较差异无统计学意义。结论宫血宁胶囊联合去氧孕烯炔雌醇片治疗子宫出血疗效显著，可有效改善患者激素水平及中医症状，值得临床推广应用。

Objective To investigate the effect of Gongxuening Capsules combined with Desogestrel Ethinylestradiol Tablets in treatment of uterine hemorrhage.Methods Patients （80 cases） with metrorrhagia in The Second People’s Hospital of Liaocheng from January 2013 to December 2014 were randomly divided into control and treatment groups. Each group had 40 cases. Patients in control group were oral administrated with Desogestrel Ethinylestradiol Tablets 150 mg for the first time within 5 d forthcoming menstruation after operation, another oral administration after 20-30 d. Then continuous oral administration were given with same time interval in turn for six times. On the basis of control group, patients in treatment group were given Gongxuening Capsules after operation, 4 grains/time, three times daily. Two groups were treated for 6 months, and 3 years was followed up. The clinical efficacy, the levels of luteinizing hormone （LH）, follicle stimulation hormone （FSH）, and estradiol （E2）, the time of control bleeding and complete hemostasis, and adverse drug reactions in two groups were compared.Results The effective rate of patients in treatment group was 97.5%, significantly higher than 77.5% of control group with significant difference （P 〈 0.05）. After treatment, the levels of LH, FSH, and E2 in two groups were significantly lower than those before treatment, and the difference was statistically significant （P 〈 0.05）; There was no significant difference in the hormone levels after treatment between two groups. The TCM syndrome scores of two groups were significantly decreased after treatment, and the degree of treatment group was significantly higher than that of control group with significant difference （P 〈 0.05）. The incidence of adverse drug reactions in treatment group was 7.5%, and there was no significant difference with that of control group. Conclusion Gongxuening Capsules combined with Desogestrel Ethinylestradiol Tablets has significant effect in treatment of metrorrhagia, and can promote the hormone level and TCM symptoms of patients effectively, which is worthy of clinical application.