甘油三酯与血糖相关指标间的关系研究

Research on the association of triglyceride with blood glucose related indices

目的分析甘油三酯（TG）与血糖相关指标间的关系。方法在江苏省6个疾病监测点的就业流动人口中,通过问卷调查、身体测量、实验室检测等方法收集人口统计学信息、行为危险因素信息以及血压、腰围、TG、空腹血糖（FPG）、餐后2 h血糖（OGTT2hr）、糖化血红蛋白（Hb A1c）等相关信息。结果分析样本为1 712名无糖尿病或血脂异常史者,平均年龄为（35.9±11.3）岁,男性占55.1%。多元线性回归分析显示,TG与OGTT2hr、Hb A1c呈线性正相关,差异具有统计学意义（P〈0.01）;在男性人群中,FPG水平也随TG水平的升高而升高,差异具有统计学意义（P〈0.05）。TG水平高于适宜切点人群（男性≥1.43 mmol/L,女性≥1.36 mmol/L）的糖尿病患病风险是低于适宜切点人群的2.95倍（95%CI：1.82~4.80）。结论 TG与FPG、OGTT2hr、Hb A1c等血糖相关指标密切相关,且TG水平升高可显著增加糖尿病的患病风险。

Objective To analyze the association of triglyceride（ TG） with blood glucose related indices. Methods Questionnaire survey,anthropometric measurement and biochemical test were employed to collect related information among occupational floating population in the 6 disease surveillance points of Jiangsu. Results 1 712 participants without pre- diagnosed diabetes mellitus or cholesterol disorder were included in this study with an average age of 35. 9 ± 11. 3,men accounted for 55. 1%.Multi- linearity regression analysis showed that TG was found to be positively associated with blood glucose of oral glucose tolerance test- 2hr（ OGTT2hr） and Hb A1c（ P〈0. 01）. Fasting plasma glucose（ FPG） significantly increased with TG among men as well,and the difference was statistically significant（ P〈0. 05）. Compared with the control group,the risk of diabetes mellitus was 2. 95（ 95% CI： 1. 82- 4. 80） times higher among participants with increased TG（ men ≥1. 43 mmol / L,women ≥1. 36 mmol / L）. Conclusion TG is closely associated with FPG,OGTT2 hr,Hb A1 c,and increased TG levels could elevate the risk of diabetes mellitus.