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Micro RNA与小G蛋白信号转导通路在心脏疾病中的研究进展 被引量：1

Research progress of micro RNA and the small G proteins associated signal transduction pathways in cardiac disease
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摘要 小G蛋白能够与鸟苷酸结合促使其下游靶点磷酸化,从而发挥其GTP酶活性。小G蛋白在信号转导、细胞骨架调节、细胞增殖、细胞周期调控、钙稳态调节、内质网应激、自噬等诸多领域发挥着重要的调节作用。本文对小G蛋白在心脏疾病中的作用机制及micro RNA对小G蛋白的调控作用作一综述。 The small G proteins （small GTPase） can be combined with guanylate and promote the phosphorylation of downstream target, displa- ying its GIP enzymatic activity. The small G proteins play an important part in cellular signal transduction, cytoskeleton regulation, cell prolifer- ation, cell cycle regulation, calcium homeostasis, endoplasmic reticulum stress, autophagy and so on. This review made a summary for the regula- tory effect of microRNA and small G proteins.
作者 张璐 尹宏丽 张莹
机构地区 哈尔滨医科大学药学院药理学教研室
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2015年第20期2073-2075,共3页 The Chinese Journal of Clinical Pharmacology
基金 国家自然科学基金资助项目(81470490)
关键词 小G蛋白 micro RNA 心脏疾病 基因调控 信号转导 small G protein micro RNA cardiac disease gene regulation signal transduction
分类号 R541 [医药卫生—心血管疾病]
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参考文献21

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二级参考文献45

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中国临床药理学杂志
2015年 第20期

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