经颅超声治疗对脑性瘫痪儿童躯体感觉功能的影响

Transcranial ultrasound can improve sensory functioning in children with cerebral palsy

目的观察经颅超声治疗对脑性瘫痪儿童躯体感觉功能的影响。方法采用随机数字表法将67例脑性瘫痪儿童分为经颅超声组（33例）及常规治疗组（34例）。2组患儿均给予常规康复治疗，经颅超声组在此基础上辅以经颅超声治疗，超声强度为1．2W／cm^2，每次治疗20min，每周治疗5次。2组患儿疗程均为3周。分别于治疗前、治疗3周后检测2组患儿N20及P37波潜伏期和波幅，同时采用Von—Frey法测定2组患儿躲避反射阈值。结果治疗前2组患儿N20及P37波潜伏期和波幅、躲避反射阈值组间差异均无统计学意义（P〉0．05）。经治疗3周后，发现常规治疗组N20及P37波潜伏期[分别为（18．24±2．80）ms和（35．21±3．89）ms]无显著变化（P〉0．05），波幅[分别为（1．26±0．24）μV和（0．97±0．27）μV]有明显提高（P〈0．05）。经颅超声组治疗后N20及P37波潜伏期[分别为（16．87±2．66）ms和（34．36±2．70）ms]均明显缩短（P〈0．05），波幅[分别为（1．59±0．25）μV和（1．23±0．37）μV]明显提高（P〈0．05），并且N20潜伏期及N20、P37波幅与常规治疗组间差异均具有统计学意义（P〈0．05）。经颅超声组治疗后Von-Frey躲避反射阈值[（1．28±0．82）g]较治疗前明显降低（P〈0．05），但与常规治疗组躲避反射阈值[（1．24±0．65）g]间差异无统计学意义（P〉0．05）。结论经颅超声治疗能显著缩短脑瘫患儿SEPs潜伏期，提高波幅，提示该疗法有助于改善脑瘫儿童躯体感觉功能。

Objective To explore the effects of transcranial ultrasound （TU） on the sensory functioning of children with cerebral palsy （ CP）. Methods Sixty-seven children with CP were randomly divided into a TU group （n = 33） and a control group （n = 34）. All of the children were given conventional rehabilitative treatment, but the children in the TU group also received TU stimulation at 1.2 W/cm^2 for 20 min daily, 5 times a week. All the treatments continued for 3 weeks in both groups. Before and after the intervention, the latencies and amplitudes of N20 and P37 were recorded and the escape reflex threshold was measured using the Von-Frey method. Results Before the treatment there were no significant differences between the two groups. After the 3 weeks of treatment, significant differences were observed in the N20 and P37 amplitudes, but not in the latencies in the control group. In TU group, however, the N20 and P37 latencies were significantly shorter and the amplitudes were significantly improved after the treatment. So significant inter-group differences were found in terms of N20 latency and both N20 and P37 amplitude after the treatment. The average escape reflex threshold in the TU group was significantly lower than before treatment, but not significantly different from the control group＇s average. Conclusions Transcranial ultrasound can effectively shorten the latencies and increase the amplitudes of somatosensory evoked potentials, suggesting that it can improve somatosensory functioning in children with CP.