妊娠期肝内胆汁淤积症对妊娠结局的影响

Effect of intrahepatic cholestasis on pregnancy outcomes

目的探讨妊娠期肝内胆汁淤积症对妊娠结局造成的影响。方法将30例妊娠期内患有肝内胆汁淤积症的孕产妇设为研究组,另55例非妊娠期肝内胆汁淤积孕产妇设为对照组,对比两组孕产妇围生期并发症发生率及新生儿(胎儿)情况。结果观察组孕产妇围生期并发症发生率(56.67%)明显高于对照组(12.72%)(P<0.05);观察组胎儿窘迫、低体质量、羊水污染、新生儿窒息发生率均高于对照组(P<0.05)。结论妊娠期肝内胆汁淤积可增加孕产妇围生期并发症发生率,导致胎儿窘迫、新生儿窒息等,胎儿预后较差。

Objective To investigate the effect of intrahepatic cholestasis on pregnancy outcomes. Methods with intrahepatic cholestasis within hospital maternity received 30 cases of pregnant women during pregnancy to the study group,and the other 55 cases of intrahepatic cholestasis of non- pregnant women classified as the control group,compared two groups of pregnant maternal perinatal morbidity and neonatal（ fetus） situation. Results There were maternal perinatal morbidity（ 56. 67%） was significantly higher（ 12. 72%）（ P〈0. 05）; observation group fetal distress,low body weight,meconium,a high incidence of neonatal asphyxia in the control group（ P〈0. 05）. Conclusion intrahepatic cholestasis increase maternal perinatal morbidity,leading to fetal distress,neonatal asphyxia,fetal prognosis is poor.