中西医结合治疗疱疹性咽峡炎35例

The Therapy of Integrated Medicine in Treating Herpangina for 35 Cases

目的探索脾氨肽口服液治疗疱疹性咽峡炎的免疫功能变化与临床疗效。方法将68例符合疱疹性咽峡炎诊断标准的患儿,随机分成两组,对照组予利巴韦林治疗,观察组加用脾氨肽口服液治疗,其余治疗方法与对照组相同,观察患儿治疗后的退热时间,疱疹消退时间,并在治疗前后进行免疫功能检测(Ig G、CD4+、CD8+、CD4+/CD8+)。结果观察组在主要症状、体征持续时间均短于对照组(P<0.05)。观察组的总有效率为91.43%,对照组的总有效率72.76%,观察组疗效优于对照组(P<0.05)。观察组患儿治疗后Ig G、CD4+、CD8+、CD4+/CD8+升高,CD8+下降,治疗前后比较差异有统计学意义(P<0.05),对照组治疗前后Ig G、CD4+、CD8+、CD4+/CD8+升高,CD8+无明显变化(P<0.05)。结论脾氨肽口服液能提高疱疹性咽峡炎患儿的免疫水平,疗效显著,值得推广应用。

Objective To explore the clinical effect and changes of immune function Spleen Aminopeptide Oral Solution in treating her-pangina. Methods 68 cases of parients with herpangina were randomly divided into control group and observation group. The control group was given ribavirin. The observation group was given Spleen Aminopeptide Oral Solution, and the other treatments were the same as the control group. The antipyretic time and herpes regression time were observed. Immune function of Ig G, CD4＋, CD8＋ and CD4＋/CD8＋were detected. Results The main syndromes and duration of physical sign of the treatment group were shorter than those of the control group（P〈0.05）. The total effective rate of the observation group was 91.43%, which was better than 72.76% of the control group（P 〈0.05）. After treatment, in the observation group, the Ig G, CD4 ＋ and CD4 ＋/CD8 ＋ increased, and CD8 ＋ decreased, and the difference was statistically significant（P 〈 0.05）. After treatment, in the control group, the Ig G, CD4 ＋ and CD4 ＋ / CD8 ＋ increased, and CD8 ＋had no significant change（ P 〈 0.05）. Conclusion Spleen Aminopeptide Oral Solution can improve the immune level of children with herpangina, the curative effect is distinct, and is worth promoting the application.