我院187例药品不良反应报告分析

Report Analysis of 187 Cases of Adverse Drug Reaction in Our Hospital

目的:了解我院药品不良反应(ADR)发生特点,促进临床合理用药。方法:收集我院2014年度上报的187例ADR报告,对发生ADR的患者年龄、性别以及药品种类、给药途径、临床表现、报告类型等进行统计分析。结果:我院ADR报告以老年人多见(≥60岁,92例,49.20%),涉及ADR的药品以心血管系统药物最多(44例,23.53%),其次为抗感染药物(34例,18.18%)和中药注射剂(33例,17.65%);给药途径以静脉给药途径为主(157例,83.96%),主要临床表现为头痛、头晕(59例,31.55%),ADR报告类型以已知、一般为主(166例,88.77%)。结论:我院临床应加强对老年人用药,心血管系统药物、抗感染药物、中药注射剂及静脉给药的监测,减少ADR的发生。

Objective： To understand the generative characteristics of the adverse drug reactions （ADRs） occurred in our hospital and to promote rational drug use in clinical practice. Methods： About 187 cases of ADR reports were collected which were submitted in our hospital in 2014, and patient’s ages, sex, involved drug species, route of administration, clinical manifestation and report types were analyzed statistically. Results： ADRs occurred in elders mainly （≥60 years old, 92, 49.20%） and mainly caused by cardiovascular drugs （44, 23.53%）, antibacterials （34,18.18%） and Chinese medicine injections （33,17.65%）, and intravenous administration （73.48% ）. The main clinical manifestations included headache and dizzy （59, 31.55% ） and the most types of ADR reports were already known or common （166, 88.77%）. Conclusion： Monitoring should be strengthened on elders, the use of cardiovascular drugs, antibacterials and Chinese medicine injections, and intravenous administration so as to reduce occurrence of ADR.