Meta-analysis on protective effect of electroacupuncture at “Nèiguān”(内关 PC 6) in rats with reperfusion injury induced myocardial ischemia

电针“内关穴”对心肌缺血再灌注损伤大鼠保护作用的Meta分析（英文）

Objective To systematically evaluate the protection effect of electroacupuncture at ＂Neiguan＂（内关 PC 6） on myocardial damage by means of evidence-based medicine.Methods Databases were retrieved by computer,while dissertation compilations and conference proceedings were searched manually.Data were analyzed statistically by using RevMan5.2software.Results Twelve studies were enrolled.Compared with myocardial ischemia reperfusion injury model group,① the magnitude of ECG STⅡ segment elevation can be reduced by means of electroacupuncture at PC 6（WMD=-73.95,95%CI[-109.69,-38.20]） and the difference was statistically significant（P0.0001）;② the ATPase in myocardial cells can be increased by means of electroacupuncture at PC 6（SMD=2.28,95%Cl[1.50,3.07]） and the difference was statistically significant（P0.00001）;③ the release of cTnT can be reduced by means of electroacupuncture at PC 6（WMD=-2.69,95%CI[-3.16,-2.22]） and the difference was statistically significant（P0.00001）;④ the size of myocardial infarction can be reduced by means of electroacupuncture at PC 6（WMD=-17.99,95%Cl[-19.88,-16.09]） and the difference was statistically significant（P0.00001）;⑤ the release of CK can be reduced by means of electroacupuncture at PC 6（WMD=-0.44,95%CI[-0.61,-0.27]） and the difference was statistically significant（P0.00001）;⑥ the release of CK-MB can be reduced by means of electroacupuncture at PC 6（SMD=-2.85,95%CI[-4.46,-1.24]） and the difference was statistically significant（P0.001）;⑦ the release of LDH can be reduced by means of electroacupuncture at PC 6（SMD=-2.97,95%CI[-4.87,-1.07]） and the difference was statistically significant（P0.01）.Conclusion Based on the current experimental evidences,electroacupuncture at PC 6 has a higher protective effect on myocardium.

目的:用循证医学的方法系统评价电针"内关"穴对心肌损伤的保护作用。方法:计算机检索数据库,手工检索学位论文汇编、会议论文集补充,收集相关文献,并用Rev Man5.2软件对数据进行分析。结果:共纳入12个研究,与心肌缺血再灌注损伤模型组比较:1电针"内关"穴可以降低心电图STⅡ段抬高幅度(WMD=-73.95,95%CI[-109.69,-38.20]),差异具有统计学意义(P<0.0001);2电针"内关"穴可以增加心肌细胞ATP酶(SMD=2.28,95%CI[1.50,3.07]),差异具有统计学意义(P<0.00001);3电针"内关"穴可以减少c Tn T的释放(WMD=-2.69,95%CI[-3.16,-2.22]),差异具有统计学意义(P<0.00001);4电针"内关"穴可以减少心肌梗死面积(WMD=-17.99,95%CI[-19.88,-16.09]),差异具有统计学意义(P<0.00001);5电针"内关"穴可以减少CK的释放(WMD=-0.44,95%CI[-0.61,-0.27]),具有统计学差异意义(P<0.00001);6电针"内关"穴可以减少CK-MB的释放(SMD=-2.85,95%CI[-4.46,-1.24]),差异具有统计学意义(P<0.001);7电针"内关"穴可以降低LDH(SMD=-2.97,95%CI[-4.87,-1.07]),差异具有统计学意义(P<0.01)。结论:基于目前实验性证据,电针"内关"穴对心肌的保护作用具有较高的有效性。