结肠移行性复合运动产生和传播机制的研究进展

Colonic migrating motor complex: Generation and propagation mechanism

结肠移行性复合运动(colonic migrating motor complex,CMMC)是一种神经介导的、周期性的收缩和电活动,是推动小鼠结肠中粪便颗粒前进的主要动力.CMMC异常对胃肠动能紊乱,尤其是慢传输型便秘有重要影响.本文以CMMC产生和传播机制为切入点,集中探讨钻膜5轻色胺(5-hydroxytryptamine,5-HT)、肠肌间5-HT神经元、肠道Cajal间质细胞(interstitial cells of Cajal,ICC)网络、蠕动反射、隐匿反射对CMMC的影响,强调内在初级传入神经元(intrinsic primary afferent neurons,IPANs)、上行兴奋性神经通路和下行抑制性神经通路的重要作用,并介绍特定神经元活动检测新方法来佐证5-HT神经元在肠道动力方面的重要价值.

The colonic migrating motor complex（CMMC）is a critical neurally mediated,cyclical contractile and electrical event.CMMC is the primary motor pattern underlying fecal pellet propulsion along the murine colon.Abnormal CMMC has important implications in a number of gastrointestinal disorders,especially slow transit constipation.This review focuses on the mechanisms involved in producing and propagating the CMMC,which is likely dependent on mucosal and neuronal serotonin and pacemaker interstitial cells of Cajal networks and how peristaltic reflexes or occult reflexes affect them,and emphasizes the important role of intrinsic primary afferent neurons,ascending excitatory and descending inhibitory neural pathways.In addition to these,we also introduce some new tools to detect specific neuronal activity so as to offer some exciting insights into the role of5-hydroxytryptamine in colonic motility.