柴胡疏肝散抗抑郁研究进展

Research Progress of Treating Depression by Chaihu Shugan Powder

柴胡疏肝散是一种临床常用的治疗抑郁症的复方。近年来,国内外学者应用现代科学方法作了大量关于柴胡疏肝散治疗抑郁症的研究。通过检索近年来国内外关于柴胡疏肝散抗抑郁研究的文献,对其相关临床及基础实验研究进行总结,表明柴胡疏肝散具有显著的抗抑郁作用,其机制可能涉及调节单胺类神经递质、保护海马神经元、调整HPA轴功能等。本文对于进一步深入研究抑郁症发病机制、新药研发及提高抑郁症的诊疗疗效有一定的参考价值。

Chaihu Shugan Powder was commonly used for the clinical treatment of depression.In recent years,researchers at home and abroad conducted lots of studies on treatment of depression by applying Chaihu Shugan powder with modern scientific methods.Through searching domestic and oversea lectures which studied on treatment of depression by applying Chaihu Shugan powder published in recent years,this article summarized relative clinical and fundamental experimental studies and indicated that that Chaihu Shugan powder had remarkable antidepressant effect.The mechanism may involve regulating monoamine neurotransmitter,protecting hippocampal neurons and adjusting HPA axis.This article could provide reference for a further study on pathogenesis of depression,new drug development and improvement of depression treatment.