代谢组学技术在证候研究中的应用进展

Application Progress of Metabonomics on the Study of TCM Syndrome

目的:了解代谢组学技术在中医证候研究中的进展。方法:按照系统评价方法,以代谢组学和证候为主题词检索国内外数据库,提取符合入选标准的文献,从代谢组学概念、中医证候、代谢组学与中医证候的关系等五方面介绍代谢组学技术的优势及其在中医证候研究中的最新研究进展。结果:代谢组学技术可以发现同一疾病不同证型的代谢产物,并最终确认其所在的代谢生化通路。结论:代谢组学技术在证候研究中得到了广泛应用,代谢组学技术有望为证候本质研究提供可靠的分析方法。

Objective：To learn the recent progress of metabonomics technology applied on the study of TCM syndrome.Methods：We searched on domestic and oversea database using metabonomics and syndrome as subject terms and selected articles which meet inclusion criteria.Based on the method of system evaluation,the advantage of metabonomics technology and its recent development of application on the study of TCM syndrome were introduced in terms of concept of metabonomics,TCM syndrome,relation between metabonomics and TCM syndrome.Results：By using the metabonomics technology,we could find out metabolites of different syndrome types of the same disease,and finally confirm its biochemical pathways.Conclusion：Metabonomics technology is widely applied in the study of TCM syndrome and it is expected to provide a credible analysis method for the study of syndrome es-