炎症介质在海水淹溺急性肺损伤发生机制中的作用

Role of inflammatory mediators in the pathogenesis of seawater drowning induced-acute lung injury

海水淹溺导致的急性肺损伤越来越受重视。其病情进展快,发病机制复杂,救治困难。淹溺导致海水吸入可激活急性炎症反应,炎症细胞、炎症因子释放可形成级联反应,引起肺局部甚至全身炎症反应综合征,多种炎症介质包括细胞因子中的肿瘤坏死因子-α、白介素-1β、白介素-6、白介素-8,核因子-κB、中性粒细胞及活性氧、蛋白酶参与了炎症反应的启动和增强过程。作者就炎症介质在海水淹溺急性肺损伤发生机制中的作用进行综述。

Increasing importance has been attached to seawater drowning induced-acute lung injury( SWD-ALI) due to its rapid progression,complicated pathogenesis and ineffective therapy.Seawater aspiration caused by drowning can activate acute inflammatory response and release inflammatory related cells and factors,which can perform cascade reaction leading to partial inflammation in lung or systemic inflammatory response syndrome. A variety of inflammatory mediators participate initiation and enhancement of inflammatory response such as cytokines including tumor necrosis factor-α( TNF-α),interleukin( IL)-1β,IL-6,IL-8,nuclear factor( NF)-κB,neutrophils,reactive oxygens,proteases and so on. In this paper,the effect of inflammatory mediators on pathogenesis of SWD-ALI is reviewed.