虎杖降脂颗粒对高脂血症大鼠降脂作用的研究

The effects of Huzhangjiangzhi granules on hyperlipidemia in rats

目的研究虎杖降脂颗粒对饮食性大鼠高脂血症的治疗作用。方法采用高脂性饮食诱导大鼠高脂血症,给予口服不同剂量的虎杖降脂颗粒,观察药物对模型动物血脂水平、体质量变化和肝脏脏器指数,肝脏脂质TC、TG,血清AST、ALT、肌酐和尿素氮以及肝脏组织形态的影响。结果虎杖降脂颗粒各剂量组大鼠肝指数及肝组织脂质TC和TG均明显下降(P<0.05或P<0.01);血清中TC、LDL-C、HDL-C含量不同程度地降低(P<0.05或P<0.01),但对TG作用不明显;血清AST、ALT有不同程度的降低(P<0.05或P<0.01),但对血清肌酐和尿素氮无明显作用。肝组织病理学结果表明,虎杖降脂颗粒各剂量组能不同程度地降低模型大鼠的肝脏脂肪变性程度。结论虎杖降脂颗粒可有效调节高脂乳剂所致高脂血症大鼠血脂和肝脂水平,对高脂血症具有较好的调脂作用。

Objective To study the therapeutic effects of Huzhang Jiangzhi Granules on hyperlipidemia in diet-induced rats. Methods The hyperlipidemia rat model was induced by administrating with high fat emulsion and different doses of Huzhang Jiangzhi Granules were given orally to rats. The effects of the drug on the levels of lipids,AST,ALT,creatinine,urea nitrogen in serum,the levels of TC,TG in liver,the liver index and morphologic changes of liver were observed. Results Huzhang Jiangzhi Granules in different doses reduced significantly the levels of liver index,liver TC and TG,serum TC,LDL-C and HDL-C,serum AST and ALT( P < 0. 05 or P < 0. 01),but had no effects on serum TG levels,serum creatinine and urea nitrogen. The results of liver histopathology indicated that Huzhang Jiangzhi Granules reduced significantly liver steatosis. Conclusion Huzhang Jiangzhi Granules can regulate hyperlipidemia in rats.