甲胎蛋白与标准化残肝体积比对原发性肝癌根治切除术后复发风险的临床评估

Clinical evaluation of the recurrence risk of primary liver cancer after resection with the ratio of alpha fetoprotein and standard remnant liver volume

目的评估甲胎蛋白（AFP）与标准化残肝体积比对原发性肝癌根治切除术后复发风险的临床价值。方法回顾2009-05～2014-09期间68例临床分期相同的行原发性肝癌根治切除术患者资料，根据随访1年有无复发进行临床分组，其中复发组32例，未复发组36例，比较两组间患者术后AFP均值与标准化残肝体积，分析AFP与标准化残肝体积比在评估原发性肝癌根治切除术后复发风险的临床应用价值。结果复发组和未复发组术后的AFP均值分别为（110．25±89．44）ng／ml和（70．71±54．32）ng／ml，标准化残肝体积分别为（371．59±27．35）mL／m^2和（462．56±61．96）ml／m^2。复发组的AFP与标准化残肝体积比均值为（0．29±0．22），高于未复发组（0．16±0．16）（P〈0．01）。结论AFP与标准化残肝体积比在评估原发性肝癌根治切除术后复发风险中有一定的临床价值，当原发性肝癌根治切除术后1年内的AFP与标准化残肝体积比超过0．2时，复发风险较高。

Objective To evaluate the clinical value of the ratio of the alpha fetoprotein( AFP) and standard remnant liver volume in the recurrence risk of primary liver cancer after resection. Methods Sixty-eight patients' clinical data were retrospectively analyzed,who were given the primary liver cancer resection in our hospital from May2009 to September 2014,with a follow-up of 1 year. They were divided into two groups according to whether the disease reoccurred or not. The recurrence group contained 32 patients,and the non-recurrence group contained 36 patients. The mean AFP and standard postoperative residual liver volume were compared between the two groups to evaluate the clinical value of the ratio of the alpha fetoprotein( AFP) and standard remnant liver volume in the recurrence risk of primary liver cancer after the resection. Results The postoperative AFP was( 110. 25 ± 89. 44) ng / ml and( 70. 71 ± 54. 32) ng/ml respectively in the recurrence group and the non-recurrence group; The standard remnant liver volume was( 371. 59 ± 27. 35) ml / m2and( 462. 56 ± 61. 96) ml / m2 respectively in the recurrence group and the non-recurrence group. The ratio of AFP to standard remnant liver volume of the recurrence group was( 0. 29 ±0. 22),which was significantly higher than that of the non-recurrence group( 0. 16 ± 0. 16)( P < 0. 01). Conclusion There is certain clinical value of the ratio of AFP to standard remnant liver volume in the recurrence risk of primary liver cancer after resection. When it exceeds 0. 2,the recurrence risk of primary carcinoma of the liver after resection will be higher in 1 year.