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蒙药忠伦阿汤干预活动期类风湿关节炎患者临床疗效及生存质量的影响

Effect of Mongolian Medicine Zhonglun A Decoction on Patients with Active Rheumatoid Arthritis Clinical Efficacy and Quality of Life
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摘要 目的:研究蒙药忠伦阿汤干预活动期类风湿关节炎的临床疗效及患者生存质量的影响。方法:将90例活动期RA患者随机分为治疗组和对照组,每组45例。对照组应用甲氨蝶呤片,治疗组在对照组基础上加用忠伦阿汤,两组疗程均为12周,观察患者治疗前后临床症状、体征、实验室指标及健康状况问卷(HAQ)积分的变化。结果:治疗12周后两组主要临床症状、体征,RF、CRP、ESR等实验室指标及HAQ积分均比治疗前明显下降(P<0.05),对照组治疗后抗CCP抗体与治疗前比较无明显差异(P>0.05);两组治疗后临床症状、体征,RF、CRP、ESR及HAQ积分组间比较有明显差异(P<0.05),抗CCP抗体组间比较无明显差异(P>0.05);治疗组出现4例胃肠道不适(其中脱落1例)病例,对照组出现3例胃肠道不适及3例皮疹(其中脱落2例)病例,经对症处理后均恢复正常,两组不良反应发生率经统计学处理无明显差异(P>0.05)。结论:蒙药忠伦阿汤对活动期类风湿关节炎有较好的临床疗效,且能够很好的改善患者的生存质量,可与抗风湿药(甲氨蝶呤片)联合使用,有较好的协同作用。 Objective:To study the Mongolian medicine Zhonglun A decoction intervention stage rheumatoid arthritis clinical efficacy and quality of life in patients with active. Methods:90 patients with active RA were randomly divided into treatment group and control group,45 cases in each group. Control group was treated with methotrexate tablets,the treatment group in the control group based and loyalty Zhonglun A decoction. The course of treatment in the two groups were for 12 weeks,observed before and after treatment in patients with clinical symptoms,signs and laboratory indicators and health status questionnaire(HAQ)integral changes. Results:After 12 weeks of treatment,two groups of clinical symptoms,signs,laboratory indexes and HAQ,RF,CRP,ESR scores were significantly decreased than those before treatment(P〈0.05),the control group after treatment with anti CCP antibody before treatment had no significant difference(P〉0.05);the two groups after treatment,clinical symptoms signs,there are significant differences between the RF,CRP,ESR and HAQ scores between the groups(P〉0.05),there were no significant difference between the groups of anti CCP antibody(P〉0.05);the treatment group had 4 cases of gastrointestinal discomfort(including 1 cases of loss cases),the control group of 3 cases of gastrointestinal discomfort and 3 cases of skin rash(including loss in 2 cases)cases,after symptomatic treatment were normal,adverse reactions of two groups were statistically no significant difference(P〉0.05). Conclusion:Mongolian medicine Zhonglun A decoction on active rheumatoid arthritis have better clinical curative effect and can improve the patient's quality of life,and antirheumatic drugs(methotrexate tablets)used in combination,have a good synergistic effect.
出处 《辽宁中医药大学学报》 CAS 2015年第10期54-57,共4页 Journal of Liaoning University of Traditional Chinese Medicine
基金 内蒙古科技厅应用研究项目(201100114)
关键词 忠伦阿汤 活动期类风湿关节炎 临床症状体征 生存质量 Zhonglun A decoction active clinical symptoms quality of life
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