摘要
上皮-间质转化(epithelial-mesenchymal transition,EMT)是指上皮细胞表型发生变化,并获得间充质细胞表型特征的转化过程。转化生长因子(TGF-β)是EMT发生过程中必不可少的诱导因子之一,可通过诱导相关因子、信号转导途径、micro RNA的表达以及肿瘤微环境的调节等介导上皮间质化的表达。该文就中药干预TGF-β介导EMT过程的不同机制作一综述。
Epithelial mesenchymal transition（epithelial-mesenchymal transition,EMT）refers to the process that epithelial cell phenotypes change and transform to the phenotype characteristics of mesenchymal cells,Transforming growth factor（TGF-β）,the essential factor on the progress of EMT,mediates the epithelial-mesenchymal transition by inducing the expression of the correlation factors,signal transduction pathway,mic RNA and the microenvironment of tumor cells.This paper aims to review researches on the different mechanisms of the process,TGF-β mediates EMT,and the effect of traditional Chinese medicines.
出处
《辽宁中医药大学学报》
CAS
2015年第10期93-96,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家中医临床研究基地业务建设科研专项课题(JDZX2012087)
江苏省卫生计生委课题(BJ14013)
关键词
EMT
TGF-Β
肿瘤
机制
中药
EMT
TGF-β
tumor
mechanism
traditional Chinese medicines
