氯烯雌酚醚联合防风通圣散对银屑病患者CRP、IL-2、IL-4、IL-10及IL-12影响研究

Study on Chlorotrianisene Combination of Fangfeng Tongsheng Powder in Patients with Psoriasis of CRP IL-2 IL-4 IL-12 and IL-10

目的:探讨氯烯雌酚醚联合防风通圣散对银屑病患者CRP、IL-2、IL-4、IL-10及IL-12影响。方法:选取我院皮肤科收治的稳定期银屑病患者92例,采用随机数字表方法将所有患者平均分为两组,各组46例,对照组予以阿维A胶囊、醋酸泼尼松龙片、甲氨蝶呤片等常规治疗,治疗组在对照组常规治疗的基础上加用氯烯雌酚醚4 mg,防风通圣散3 g,日3次口服。分别检测两组患者治疗前后血清中CRP、IL-2、IL-4、IL-10及IL-12水平,根据患者治疗前后皮损程度及病情状况采用PASI评分法判定治疗效果。结果:1与治疗前相比,两组患者治疗后CRP、IL-2及IL-12水平明显降低,而IL-4、IL-10水平明显升高(P<0.05);2治疗后与对照组相比,治疗组血清中CRP、IL-2及IL-12水平明显降低,而IL-4、IL-10水平明显升高(P<0.05);3治疗组治疗后临床总有效率(93.48%)明显高于对照组临床总有效率(78.26%)(P<0.05)。结论:氯烯雌酚醚联合防风通圣散能够降低银屑病患者血清中CRP、IL-2及IL-12水平,提高IL-4、IL-10水平,改善皮损程度,提高临床治疗疗效,对临床具有重要的临床应用价值。

Objective：To investigate the chlorotrianisene combination of Fangfeng Tongsheng Powder in patients with psoriasis of CRP,IL-2,IL-4,IL-12 and IL-10. Methods：92 patients with psoriasis from our hospital were selected and divided into control group and experiment group by Using random number table method.Control group were treated by Acitretin Capsules,Prednisolone Acetate Tablets,Methotrexate Tablets and other conventional treatment.Experiment group were treated on the base of control group with chlorotrianisene 4 mg,Fangfeng Tongsheng Powder 3 g. Serum levels of CRP,IL-2,IL-4,IL-10 and IL-12 were compared before and after treatment.According to the patients before and after treatment in patients with skin lesions and disease status using PASI score method to determine the treatment effect. Results：Compared with before treatment,CRP,IL-2 and IL-12 levels were lower（P〈0.05）,IL-10,IL-4 level were higher（P〈0.05）. Compared with control group after treatment,Serum levels of IL-12,IL-2 and CRP were lower（P〈0.05）,IL-10,IL-4 level were higher（P〈0.05）.The total effective rate of treatment group（93.48%）was significantly higher than that of the control group（78.26%）（P〈0.05）. Conclusion：Chlorotrianisene joint Fangfeng Tongsheng scattered in sera of patients with psoriasis CRP,IL-2 and IL-12 levels can be reduced,to improve the level of IL-4 and IL-10,improve the degree of skin lesions,improve the clinical efficacy,the clinical has important value in clinical application.