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水禽专用高致病性禽流感疫苗临床免疫效果初探 被引量:1

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摘要 本研究通过对试验组水禽(鸭)免疫禽流感灭活疫苗(H5N2亚型D7株)、对照组免疫重组禽流感病毒(H5N1亚型)细胞灭活疫苗(Re-6株),在免疫前及免疫后15d、21d、36d、51d和66d分别进行免疫抗体监测及病毒核酸监测,结果显示:免疫后各试验组动物的抗体水平均显著性高于对照组(P〈0.05),且试验组之间差异不显著(P〉0.05)。试验组和对照组的免疫抗体合格率均为100%,达到合格标准。免疫后试验组和对照组的抗体水平呈逐渐上升的趋势,并在第15d可达到较高的免疫抗体,获得较强的免疫保护,其中试验组抗体水平为6.9~7.3 log2,对照组为6.2 log2。直至免疫后66d,试验组的抗体水平为8.10~8.75 log2,对照组为6.3log2。免疫前试验组和对照组抗体离散度都比较高,均在60%以上,最高可达到107.34%;免疫后抗体离散度比较低,均在30%以下。通过比较分析,禽流感灭活疫苗(H5N2亚型D7株)对水禽的免疫效果要优于重组禽流感病毒(H5N1亚型)细胞灭活疫苗(Re-6株)。
出处 《中国畜牧兽医文摘》 2015年第9期208-209,171,共3页
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