结肠癌152例根治术后临床预后因素分析

Analysis of prognostic factors in 152 patients after radical resection of colon cancer

目的探讨影响结肠癌患者预后的影响因素,为临床治疗提供依据。方法选择性别、年龄、肿瘤大小、肿瘤部位、大体分型、分化程度、浸润深度、淋巴结转移、远处转移、癌胚抗原(CEA)、化疗、Dukes分期共计12项临床病理指标,用单因素和多因素分析的方法研究其对152例结直肠癌患者预后的影响。结果单因素分析提示:肿瘤大体类型、分化程度、浸润深度、淋巴结转移、远处转移、CEA指数和Dukes分期均为影响预后的因素(P均<0.01),而性别、年龄、肿瘤的大小、肿瘤部位、化疗则未显示对预后有影响(P>0.05);多因素分析提示:分化程度、淋巴结转移、CEA指数(P均<0.05)和大体类型(P<0.01)均为预后的独立影响因素,在这些独立影响因素中大体类型与预后的关系最为密切。结论分化程度、淋巴结转移、CEA指数和大体类型均为预后的独立影响因素。

Objective To investigate the influencing factors of prognosis of colon cancer, and provide the basis for clinical treatment. Methods A total of 12 clinical and pathological indicators including gender, age, tumor size, tumor location, gross type, differentiation, invasion depth, lymph node metastasis, distant metastasis, CEA and chemotherapy, Dukes staging were se- lected, single factor and multivariate analysis method was used to study the effects of the above indexes on the prognosis of 152 patients with colon cancer. Results Univariate analysis showed： gross type, tumor differentiation, depth of invasion, lymph node metastasis, distant metastasis, CEA and Dukes stage （P all 〈 0. 01 ） were prognosis influencing factors. However, gender, age, tumor size, tumor location, chemotherapy factors had no effect on prognosis （ P 〉 0. 05 ）. Cox regression analysis showed that ： the degree of differentiation, lymph node metastasis, CEA （ P all 〈 0. 05 ）, gross type （ P 〈 0. 01 ） were independent prog- nosis influencing factors. Among the independent prognosis influencing factors, gross type was closely correlated with prognosis. Conclusion The degree of differentiation, lymph node metastasis, CEA and gross type were independent prognosis influencing factors.