氟西汀与艾司西酞普兰对老年抑郁症患者外周血红细胞免疫能力的影响

Effect of fluoxetine and escitalopram on peripheral blood erythrocyte immune function in elderly patients with depression

目的探讨氟西汀与艾司西酞普兰对老年抑郁症患者外周血红细胞免疫能力的影响。方法选取100例老年抑郁患者为研究对象,随机分为氟西汀组50例和艾司西酞普兰组50例。氟西汀组给予氟西汀(20 mg/d),艾司西酞普兰组给予艾司西酞普兰(5 mg/d)。比较两组患者红细胞花环(DTER)、红细胞C3b受体花环(RBC-C3bRR)、红细胞免疫复合物花环(RBC-ICR)及临床疗效。结果艾司酞普兰组DTER、RBC-C3bRR均显著降低,RBC-ICR显著升高,与氟西汀组比较差异有统计学意义(P<0.05)。氟西汀组与艾司酞普兰组治疗有效率(86.0%vs 90.0%)比较差异未见统计学意义(P>0.05)。结论艾司西酞普兰可有效提高老年抑郁症患者外周血红细胞免疫能力,其效果优于氟西汀。氟西汀与艾司西酞普兰治疗老年抑郁症的临床疗效相似。

Objective To evaluate the effect of fluoxetine and escitalopram on peripheral blood erythrocyte immune function in elderly patients with depression. Methods One hundren elderly patients with depression were randomly divided into fluoxe- tine group（ n = 50）and escitalopram group（ n = 50）. The fluoxetine group was given fluoxetine treatment and escitalopram group was given escitalopram treatment. The DTER, RBC-C3bRR, RBC-ICR and clinical effects were compared between the two groups. Results In escitalopram group, the DTER and RBC-C3bRR significantly decreased, the RBC-ICR significantly in- creased, compared with fluoxetine group, the differences were significant （ P 〈 0. 05 ）. The clinical effects of two groups（ 86. 0% vs 90. 0% ） had no significant difference （P 〉 0. 05）. Conclusion Escitalopram can effectively improve the peripheral blood e- rythrocyte immune function of elderly patients with depression, the effect is better than that of fluoxetine. Fluoxetine or escitalo- pram treatment is similar in the clinical curative effect of elderly patients with depression.