颈动脉支架植入与药物治疗对脑梗死合并认知功能障碍的对比研究

Comparative study of underwent carotid stent implantation and drug therapy in patients with cerebral infarction combined cognitive impairment

目的探究颈动脉支架植入术对脑梗死合并认知功能障碍患者支架植入后认知功能的影响。方法选取有认知功能障碍的脑梗死患者80例,在常规治疗的基础上,将有适应证的45例患者行颈动脉支架血管成形术(支架组),未行支架治疗的35例患者给予药物治疗(药物组)。在治疗前及治疗后1、3、6个月应用简易精神状态检查量表(MMSE)、蒙特利尔认知功能量表(Mo CA)、日常生活能力量表(Barthel指数)来观察认知功能的变化。结果经治疗6个月的药物组和手术后1、3、6个月的支架组在MMSE、Mo CA评分及Barthel指数明显提高,与治疗前相比有统计学意义(P<0.05);支架组MMSE、Mo CA评分及Barthel指数较药物组相比亦有明显提高,两者相比有统计学意义(P<0.05)。结论颈动脉支架植入术可改善脑梗死合并认知功能障碍患者的认知功能障碍。

Objective To study the influence of cognitive impairment of underwent carotid stent implantation in patients with cerebral infarction combined cognitive impairment. Methods Of the 80 patients with cerebral infarction combined cognitive impairment, based on the routine treatment, 45 patients with indication in stent group were treated with underwent carotid stent transluminal angioplasty, and the other 35 patients in drug group were treated with drug therapy. To observe the changes of cognitive function by mini mental state examination（MMSE）, Montreal cognitive function scale（Mo CA）, daily living measuring scale（Barthel index） before treatment and treatment after 1, 3, 6 months. Results The MMSE, Mo CA score, and Barthel index in drug group after treatment 6 months and in stent group after operation 1, 3, 6 months were obviously increased compared with before treatment, the differences was statistically significant（P〈0.05）, and which in stent group was obviously increased compared with which in drug group, the differences was statistically significant（P〈0.05）. Conclusion Underwent carotid stent implantation could improve the cognitive impairment in patients with cerebral infarction combined cognitive impairment.