2型糖尿病患者高血糖状态对肾功能的影响

Study on the effect of renal function of type 2 diabetes mellitus patients with hyperglycaemia state

目的探讨2型糖尿病患者高血糖状态对肾功能的影响。方法选择我院2013年10月~2014年5月收治的142例2型糖尿病患者为研究对象,根据血糖状态分为高血糖状态组[空腹血糖（FPG）≥7.0 mmol/L、餐后2h血糖（2h PG）≥11.1 mmol/L）]65例和达标血糖状态组（FPG〈7 mmol/L、2h PG〈11.1 mmol/L）77例,观察两组患者的FPG、2h PG、糖化血红蛋白（Hb A1C）测定值以及尿微量白蛋白（尿m ALB）、尿β2-微球蛋白（尿β2-MG）水平。结果高血糖状态患者的FPG、2h PG、Hb A1C分别为（9.10±1.85）mmol/L、（12.94±1.73）mmol/L、（8.56±1.49）%,显著高于达标血糖状态患者的（6.17±1.48）mmol/L、（9.82±1.90）mmol/L、（6.74±1.10）%,组间差异均有统计学意义（P〈0.05）;高血糖状态患者的肾功能指标尿m ALB、β2-MG分别为（32.60±2.94）mmol/L、（0.45±0.06）mmol/L,均显著高于达标血糖状态患者的（28.92±2.35）mmol/L、（0.38±0.05）mmol/L,组间差异均有统计学意义（P〈0.05）。结论 2型糖尿病患者高血糖状态对肾功能具有不良影响,显著降低患者的尿m ALB、β2-MG水平,应积极降血糖治疗、防止肾脏并发症。

Objective To investigate the effect of renal function of type 2 diabetes mellitus patients with hyperglycaemia state. Methods From October 2013 to May 2014 in our hospital, 142 cases of type 2 diabetes mellitus patients were selected as the objects in this study, they were divided into hyperglycemia state group [fasting plasma glucose（FPG） ≥ 7.0 mmol / L, 2h postprandial glucose（2h PG） ≥ 11.1 mmol / L）] and standard glucose state group（FPG 7 mmol / L, 2 h PG 11.1 mmol / L） groups, the patients＇ FPG, 2 h PG, glycated hemoglobin（Hb A1C） measured values and microalbuminuria（urinary m ALB）, urinary β2- microglobulin（urinary β2-MG） levels of two groups were compared. Results The FPG, 2h PG, Hb A1 C of hyperglycemia state group were（9.10±1.85） mmol/L,（12.94±1.73） mmol/L,（8.56±1.49）%, significantly higher than（6.17±1.48） mmol/L,（9.82±1.90）mmol/L,（6.74±1.10）% of standard glucose state group, there were significant differences between two groups（P〈0.05）; the urine m ALB, β2-MG of hyperglycemia state group were（32.60±2.94） mmol/L,（0.45±0.06） mmol/L, significantly higher than（28.92±2.35）mmol/L,（0.38±0.05） mmol/L of standard glucose state group, there were significant differences between two groups（P〈0.05）. ConclusionHyperglycemia in patients with type 2 diabetes has an adverse effect on the renal function state, can significantly reduce the patients＇ urinary m ALB, β2-MG levels, should actively hypoglycemic treatment to prevent renal complications.