2项指标联合检测对高尿酸血症合并糖尿病患者肾损伤的影响

Effect of 2 Indexes Combined Detection on Renal Injury in Patients With Hyperuricemia Complicated With Diabetes Mellitus

目的探讨尿微量清蛋白及血清胱抑素C(Cys C)联合检测对高尿酸血症合并糖尿病患者肾损伤的影响。方法选择我院300例高尿酸血症合并糖尿病患者,根据尿蛋白定性结果分为尿蛋白阳性组和尿蛋白阴性组,尿蛋白阳性组患者150例,尿蛋白阴性组患者150例,两组患者同时检测尿微量清蛋白(UMA)、Cys C、血肌酐(Scr)及尿素氮(BUN)水平,并观察各项指标阳性率。结果两组患者UMA、Cys C阳性率及2项指标联合检测阳性率均高于Scr、BUN阳性率,差异均有统计学意义(P<0.05),尿蛋白阳性组中,UMA、Cys C阳性率及2项指标联合检测阳性率均高于尿蛋白阴性组对应各指标,差异有统计学意义(P<0.05),在尿蛋白阴性组中,UMA阳性率高于Cys C阳性率,差异有统计学意义(P<0.05),2项指标联合检测阳性率均高于UMA、Cys C阳性率,差异有统计学意义(P<0.05)。结论 UMA、Cys C联合检测高尿酸血症合并糖尿病患者可提高诊断肾损伤的敏感性。

Objective To study the effects of combined detection of urine microalbumin and serum cystatin C on renal injury of patients with hyperuricemia combined with diabetes mellitus.Methods 300 cases of patients with hyperuricemia combined with diabetes mellitus were divided into the urine protein positive group and urine protein negative group according to the basis of qualitative urine protein, In the urine protein positive group 150 patients, 150 patients with proteinuria negative group, simultaneous detection of urinary albumin （UMA）, serum cystatin C CysC, serum creatinine （Scr）, biood urea nitrogen （BUN） of two groups of patients, the positive rate of the above index was observed.Results The positive rate of CysC and UMA and the combined detection in the two patients was higher than the positive rate of Scr, BUN, there was signiifcant （P〈0.05）, the positive rate of CysC and UMA and the combined detection in the urine protein positive group was significantly higher than that of urine protein negative group, the difference was statistically significant （P〈0.05）, the positive rate of UMA in the urine protein negative group was higher than that of the positive rate of CysC, the difference was statistically signiifcant （P〈0.05）, the positive rate of combined detection were higher than that of UMA, CysC, the difference was statistically signiifcant （P〈0.05）. ConclusionThe combined detection of urine microalbumin and serum CysC can improve the sensitivity of diagnosis of renal injury in patients with hyperuricemia combined with diabetes.