40例伴胸腺瘤的重症肌无力的临床特点及预后分析

Analysis of Clinical Characteristics and Prognosis of 40 Cases of Myasthenia Gravis With Thymoma

目的研究分析伴胸腺瘤的重症肌无力的临床特点及预后分析。方法抽取我院收治的40例胸腺瘤的重症肌无力患者作为研究对象,分析其Osserman临床分型、胸腺瘤组织学特征、手术后复发重症肌无力的发生率以及患者预后的情况。结果伴胸腺瘤的重症肌无力患者的Osserman临床分型以ⅡB型最多,为45.00%(18/40),胸腺瘤病理的组织学分型以B2型最多见,为47.50%(19/40)。其中有7.50%的患者在术后6个月内发生肌无力症状复发,有12.50%的患者在术后康复过程中肌无力症状加重,有5.00%的患者死于伴胸腺瘤的重症肌无力危象。结论伴胸腺瘤的重症肌无力疾病病情十分复杂,肿瘤症状容易复发且易转移,危险系数很高,有一定的病危死亡率。

Objective To investigate and analyze the myasthenia gravis with thymoma, the clinical features and prognosis.Methods 40 cases of thymoma patients with myasthenia gravis were chosen as research subjects in our hospital, analyze the Osserman clinical classification. Thymoma histologic features, the incidence of recurrence myasthenia gravis after surgery, and the prognosis of patients.Results The patients with myasthenia gravis with thymoma Osserman clinical classification withⅡB were most, and It was 45.00% （18/40）, the most common type of the thymoma histologic pathology was B2, and It was 47.50% （19/40）, there were 7.50% of the patients in the postoperative having the recurrence of symptoms of muscle weakness in 6 months. There were 12.50% of the patients in the postoperative rehabilitation process gravis symptoms worsening. There were 5.00% of patients died of thymoma myasthenia gravis crisis.Conclusion The condition of the myasthenia gravis with thymoma is very complicated, cancer symptoms is easy to relapse and transfer. The risk factor of the metastasis is high. There are certain critically ill mortality.