糖皮质激素治疗亚急性甲状腺炎的临床疗效观察

Clinical Curative Effect Observation of Corticosteroids in the Treatment of Subacute Thyroiditis

目的探讨糖皮质激素治疗亚急性甲状腺炎的临床效果。方法选取本院2011年3月～2015年3月收治的54例亚急性甲状腺炎患者为研究对象,按照随机数字表法将54例研究对象分为A组和B组,每组各27例,A组患者根据临床症状和实验室检查进行减量和停药,B组患者根据超声检查结果进行减量和停药,观察并比较两组患者的不良反应和复发情况。结果两组患者经过治疗后临床症状均消失、血沉和甲状腺激素均恢复正常,随访2个月后,A组患者的复发率为11.1%,B组为3.7%,B组患者的复发率低于A组,差异有统计学意义（P〈0.05）。A组患者的不良反应发生率为37.0%,高于B组的22.2%,两组间差异有统计学意义（P〈0.05）。结论糖皮质激素治疗亚急性甲状腺炎的效果确切,根据超声检查结果指导用药可降低复发率和不良反应的发生率。

Objective To explore the clinical effect of corticosteroids in the treatment of subacute thyroiditis.Methods 54 patients with subacute thyroiditis were selected as the research object in our hospital from March 2011 to March 2015, they were divided into group A and group B according to random number table method, the 27 cases in each group, group A of patients according to clinical symptoms and laboratory examination and reducing drug withdrawal, group B patients according to the results of ultrasound examination and reducing drug withdrawal, the two groups of patients with adverse reaction and recurrence were observed and compared. ResultsThe clinical symptoms disappeared after treatment in two groups of patients, the blood sedimentation and thyroid hormones were back to normal, follow-up after two months, the recurrence rate was 11.1% in group A of patients, group B was 3.7%, the recurrence rate in group B was lower than that in group A, the difference was statistically signiifcant （P〈0.05）. The incidence of adverse reactions was 37.0% in group A of patients, it was signiifcantly higher than that of group B 22.2% , the differences between the two groups was statistically signiifcant （P〈0.05）.Conclusion The effect of glucocorticoid treatment of subacute thyroiditis, exactly according to the results of ultrasound guiding drug can reduce the recurrence rate and the incidence of adverse reactions.