中医药综合疗法治疗卵巢储备功能不足效果分析

Effect analysis of combined therapy of traditional Chinese medicine treatment of deficient ovarian reserve

目的观察中医药综合疗法治疗卵巢储备功能低下或不足的临床效果。方法将98例卵巢功能不足患者随机分为两组。治疗组56例,采用中医药综合疗法(一般治疗;药膳茶饮;艾灸;口服调经促孕丸、坤泰胶囊)。对照组42例,单用坤泰胶囊口服。3个月为1个疗程。观察治疗前后临床症状改善情况;血清激素水平血清雌二醇(E2)、促卵泡素(FSH)、黄体生成素(LH)的变化;阴超下卵巢体积、子宫内膜厚度,卵泡数量的变化情况。结果治疗组56例,治愈49例,好转6例,未愈1例,治愈率87.50%,总有效率为98.21%。对照组42例,治愈22例,好转14例,未愈6例,治愈率52.38%,总有效率为85.71%。两组治愈率、总有效率比较,差异有统计学意义(P<0.05)。治疗后两组临床症状消失,E2、FSH、LH治疗组治疗前后比较,差异有统计学意义(P<0.05)。两组治疗前后阴超检查指标比较,具有统计学意义(P<0.05)。结论中医药综合疗法治疗卵巢储备功能不足,较单纯用坤泰胶囊效果明显。

Objective To observe the clinical effect of combined therapy of traditional Chinese medicine in the treatment of decreasing or deficient ovarian reserve. Methods 98 patients with deficient ovarian reserve were randomly divided into two groups.56 patients in treatment group were treated with combined therapy of traditional Chinese medicine（general treatment, drinking tea as medicinal diet,moxibustion, persral tiao jing cu yun pill and kun tai capsule）,while 42 patients in control group were treated with single peroral kun tai capsule,with 3 months treatment as one course.To observe the improvement condition of clinical symptoms pre and post treatment,such as the changes of serum hormone levels of estradiol（E2）, FSH,and luteinizing hormone（LH）,the change situation of ovarian volume and endometrial thickness transvaginal ultrasound, follicle numbers. Results Of 56 cases in treatment group,there were 49 cases of cured,6 cases of improvement,1 case of uncured,with the cure rate of 87.50%,the total effective rate of 98.21%.Of 42 cases in control group,there were 22 cases of cured,14 cases of improvement,6 cases of uncured,with the cure rate of 52.38%,the total effective rate of 85.71%.The differences of the cure rate and the total effective rate between the two groups were statically significant（P〈0.05）.The clinical symptoms after treatment of the two groups had disappeared,the differences of E2,FSH,LH in the treatment pre and post treatment were statically significant（P〈0.05）.The comparison of examination indexes by transvaginal ultrasound pre and post treatment between the two groups was statically significant（P〈0.05）. ConclusionCombined therapy of traditional Chinese medicine in the treatment of deficient ovarian reserve has obviously effect compared with single peroral kun tai capsule.