尿毒清颗粒治疗慢性肾脏病4期患者疗效观察

Clinical Observation of Niaoduqing Granules in Treatment of Chronic Kidney Disease Periodicals 4

目的观察尿毒清颗粒对慢性肾脏病4期的疗效。方法 36例CKD4期患者随机分为对照组、尿毒清常规剂量组、尿毒清大剂量组,对照组给予基础治疗,常规剂量组每日口服25g尿毒清颗粒,大剂量组每日口服40g尿毒清颗粒,疗程为3个月。检测各组治疗前后的血尿素氮(BUN)、肌酐(Scr)、尿酸(UA)、血红蛋白(Hb)、肾小球举步滤过率(e GFR)。结果 3组临床疗效比较差异有统计学意义(P<0.05);尿毒清不同剂量组的BUN、Scr、UA、e GFR均较治疗前下降,而Hb无改变,且分别与对照组治疗后比较,差异有统计学意义(P<0.05)。结论尿毒清颗粒能有效治疗慢性肾脏疾病,但大剂量使用效果更明显。

Objective To observe the clinical efficiency of Niaoduqing granules in treatment of chronic kidney disease 4. Methods 36 cases with CKD4 were randomly divided into control group,conventional doses group and large doses group. The control group was treated with basic treatment alone. The conventional doses group was added with oral uremic clearance granules 25 grams. The large doses group was added with oral uremic clearance granules 40 grams. All treated for 3 months. The serum of BUN,Scr,UA,Hb,e GFR were measured respectively before and after the treatment. Results There had significant difference in three groups of the clinical effect（ P〈0. 05）; the serum of BUN,Scr,UA,e GFR after the treatment of large doses group and conventional doses group decreased than before treatment,but no change in Hb. The serum of BUN,Scr,UA,e GFR after the treatment of large doses group and conventional doses group were significanct difference compared with control group（ P〈0. 05）. Conclusion Uremic Clearance granules can be effective in treating chronic kidney disease,large doses is more effective.