骨组织细胞传递生物力学刺激的信号通路的研究进展

Current Concepts in Mechanical Stimuli on Bone Remodeling

已有大量研究表明生物力学刺激对骨形成,骨改建起重要作用。成骨细胞、破骨细胞以及骨细胞通过各类感受器例如整合素、黏着斑、钙黏着蛋白等可以接受外界的生物力学刺激,接着激活下游不同的信号通路如MAPK通路、β-catenin通路、G蛋白通路等,并将信号进行传导,由此影响骨组织的生长、代谢。本篇综述将对骨细胞内传递生物力学刺激的信号通路做进展汇总。

A wide range of researches have demonstrated that mechanical stimuli play an important role in bone formation and remodeling.Osteoclasts,osteoblasts and osteocytes are able to perceive external mechanical stimuli through various sensors such as integrins,focal adhesion and cadherin,and then activate downstream signaling pathways including MAPK pathways,β-catenin pathways,and GTPase cascades,to affect the development and metabolism of bone tissue.This review intends to expound recent progress in this field,of signaling pathways related to mechanical stimuli.