组织蛋白酶K与口腔颌面部疾病

Cathepsin K and stomatognathic diseases

组织蛋白酶K(cathepsin K,CTSK)曾被认为是破骨细胞特异性的胶原酶,在骨吸收过程中发挥重要作用。但随着研究的深入,人们发现CTSK在更加广泛的细胞、组织及器官中均有表达,不仅参与机体正常生理活动的调节,还与多种疾病的发生发展密切相关。本文综述了CTSK在牙周炎、种植体周围炎、牙齿移动、口腔颌面部肿瘤、牙根吸收及根尖周病等口腔颌面部疾病中的研究进展。

Cathepsin K（ CTSK） was once regarded as a collagenase specifically expressed by osteoclasts and played an important role in bone resorption. However,more and more research found that CTSK was expressed in more extensive cells,tissues and organs. It may not only participate in regulating human physiological activity,but also be closely related to a variety of diseases. This paper reviewed the research progress on the role of CTSK in stomatognathic diseases including periodontitis,peri-implantitis,tooth movement,oral and maxillofacial tumor,root resorption and peri-apical disease.