克林霉素棕榈酸酯分散片在社区获得性呼吸道感染中的应用

Application of clindamycin palmitate hydrochloride dispersible tablet in community-acquired respiratory tract infection

社区获得性呼吸道感染是临床常见的感染性疾病之一,具有较高的患病率,其常见的病原菌包括肺炎链球菌、流感嗜血杆菌、卡他莫拉菌、金黄色葡萄球菌及厌氧菌。本文对国内社区获得性呼吸道感染的现况进行了分析,国内几项细菌耐药性监测结果显示,青霉素、头孢菌素仍是治疗的首选,而口服克林霉素新剂型——克林霉素棕榈酸酯分散片(凯莱克林),虽然对革兰阳性菌的抗菌作用稍弱,但有毒性低,过敏反应少,口服吸收率高,胃肠道反应小,以及对厌氧菌作用好等优势,使其在社区获得性呼吸道感染的治疗中拥有一席之地,对肾功能的影响小,也使得此药在老年人中使用的安全性提高。

Community-acquired respiratory tract infection（RTI） is one of the most common clinical infectious diseases with a higher morbidity, which is generally caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus and anaerobes. The current situation of community-acquired RTI in China was analyze, and several nationwide surveillance of bacterial resistance indicated that penicillins and cephalosporins were still the preferred choice for the clinical treatment of community-acquired RTI. Clindamycin palmitate hydrochloride dispersible tablet（Gloria Brooklyn） is a novel oral dosage form of clindamycin. Although it is slightly less effective against gram-positive bacteria compared with the above-mentioned antibacterials, it has still captured a fair market share due to its advantages of low toxicity, less allergies, good oral absorption rate, weak gastrointestinal side effects and high potency for anaerobes. Meanwhile, its insignificant effects on renal function can also improve the safety when it is used in elderly patients.