国内单独应用左卡尼汀与联合其他药物治疗少弱精子症有效性的Meta分析

L-carnitine alone vs.L-carnitine-based combination therapy on male infertility:a Meta-analysis

目的应用Meta分析方法评价少弱精子症患者单独应用左卡尼汀与左卡尼汀联合其他药物治疗后精液质量改善的总有效率的变化。方法检索万方数据库、中国知网期刊数据库、中国生物医学文献数据库等数据库,全面收集相关文献。制定文献纳入标准,观察指标包括妊娠率、精子密度、精子活率及前向运动精子率,制定疗效等级评价标准。应用ReviewManager 5.2软件进行Meta分析。结果本项研究共有981名少弱精子患者入选,Meta分析结果显示采用口服左卡尼汀联合其他多种生精药物后的治疗总有效率明显高于单纯服用左卡尼汀口服液。结论应用左卡尼汀联合其他不同机制的生精药物治疗少弱精子症时比单独应用左卡尼汀具有更加积极的治疗效果。

Objective To compare the clinical efficacy of L-carnitine therapy alone and L-carnitine-based combination therapy in improving semen quality of patients with oligo-astheno-teratozoospermia.Methods Databases such as Wanfang,CNKI,and Chinese Bio-medical Literature Database were searched.Studies were evaluated and extracted by two reviewers independently with designed extraction form.The indexes included pregnancy rate,sperm concentration,sperm motility and forward motility rate.Then different categories of efficacy evaluation were formulated using PEDro Scale.Data were analyzed with RevMan 5.2 software.Results A total of 8 studies involving 981 participants were included.Meta-analysis showed that compared to L-carnitine alone,L-carnitine-based combination therapy had a higher semen quality improving rate[OR=3.46,95%CI（2.54,4.72）].Conclusion L-carnitine-based combination therapy can moderately improve semen quality and is effective in treating male infertility than L-carnitine alone.