首发抑郁症患者认知功能损害及认知行为治疗

Cognitive Impairment and Cognitive Behavioral Therapy in Patients With First Episode Depression

目的 分析首发抑郁症患者认知功能损害特点,并探讨认识行为治疗对患者认知功能的影响。方法 选取本院2014年3月~2015年3月收治的首发抑郁症患者80例（观察组）和健康体检者50例（对照组）作为研究对象。采用韦氏记忆量表（WMS）、斯特鲁色词测验（Stroop）以及持续性操作试验（CPT）对两组患者进行认知功能测试。并给予80例患者认识行为治疗联合药物治疗,治疗8周后,采用上述指标和17项密尔顿抑郁量表（HAMD）评定治疗效果。结果 观察组WMS评分、Stroop评分、CPT评分与对照组比较,均低于对照组（P〈0.05）;采用药物联合认知行为干预治疗后的HAMD评分均得到改善（P〈0.05）。结论 首发抑郁症患者广泛存在严重的认识功能损害,采用认识行为联合药物治疗可有效缓解患者抑郁状态和改善认知功能。

Objective Analyzing the characteristics of the patients with first-episode depression cognitive impairment,and to explore the influence of cognitive behavioral therapy in patients. Methods Selected 80 patients with first-episode depression（observation group）and 50 cases of healthy physical examination（control group）as the research object in our hospital from March 2014 to March 2015. Using wechsler memory scale（WMS）,the Stroop colour word test（Stroop）and continuous operation test（CPT）for two groups of cognitive function test. And 80 cases of patients＇ combined cognitive behavioral therapy and drug for therapy, after 8 weeks,using the above indexes and 17 Milton depression scale（HAMD）to evaluate the therapeutic effect. Results Observation group＇WMS score, Stroop score, CPT score compared with control group,were significantly worse than control group（P〈0.05）. After using drugs with cognitive behavioral therapy,HAMD scores were improved significantly（P〈0.05）. Conclusion First-episode depression exist in patients with severe cognitive function damage and cognitive behavioral therapy combined with drug therapy can effectively relieve depression and improve cognitive function in patients.