47例呼吸机相关性肺炎患者临床分析

Clinical Analysis of 47 Cases With Ventilator Associated Pneumonia

目的研究呼吸机相关性肺炎(VAP)的临床及病原学特点,总结防治VAP的有效途径。方法回顾性分析47例呼吸机相关性肺炎(VAP)患者的临床资料,观察其中的病原体分布及其药敏情况。结果细菌培养阳性菌主要为绿脓杆菌26例,占55.3%,肺炎克雷伯杆菌9例,占19.2%,大肠杆菌8例,占17.1%,金黄色葡萄球菌阳性4例,占8.5%,药敏试验敏感抗菌素主要为亚胺培南、丁胺卡那霉素、哌拉西林舒巴坦钠及三代菌素。结论革兰阴性菌是VAP的主要致病菌,正确有效地使用抗菌素是治疗VAP的关键。

Objective To study the clinical and pathogenic characteristics of ventilator associated pneumonia（VAP）,and to summarize the effective methods of preventing and controlling VAP. Methods The clinical data of 47 patients with ventilator associated pneumonia（VAP）were retrospectively analyzed,and the distribution of pathogens and drug sensitivity were observed. Results For bacterial culture,positive bacteria mainly was Pseudomonas aeruginosa in 26 cases, accounting for 55.3%,9 cases of Klebsiella pneumoniae,accounted for 19.2%,8 cases of Escherichia coli,17.1%,Staphylococcus aureus was positive in 4 cases,accounted for 8.5%. For susceptibility test, sensitive antibiotics mainly were Imipenem, amikacin, piperacillin sulbactam and three generation cephalosporin. ConclusionGram negative bacteria are the main pathogens of VAP,the correct use of antibiotics is the key measure for treatment of VAP.